Iturin A-2, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ451)
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Iturin A-2 is a cyclic lipopeptide discovered in B. subtilis and exhibits inhibitory activity against the plant pathogenic fungus P. expansum (MIC = 8 µg/disk). Iturin A-2 is cytotoxic to MCF-7 and BT474 breast cancer cells, as well as HeLa cervical cancer cells, with IC50 values of 66.81, 95.04, and 77.5 µg/mL, respectively. In greenhouse studies, Iturin A-2 at concentrations of 100 and 300 mg/kg Iturin A-2 reduces the lesion area of southern corn leaf blight caused by B. maydis, and in field studies, concentrations of 300 and 500 mg/kg Iturin A-2 reduce the incidence of the disease. Iturin A-2 (12.5 µg/mL) inhibits cell division, but not nuclear division, in isolated fertilized starfish eggs.
| Overview | |
|---|---|
| Synonyms | Iturin A-2; Iturin A2 |
| Source | Bacteria |
| CAS | 83785-07-3 |
| Molecular Formula | C48H74N12O14 |
| Molecular Weight | 1043.23 |
| Sequence | Cyclo({d-Asn}-Gln-Pro-{d-Asn}-Ser-{(3R)-3-aminotetradecanoic acid}-Asn-{d-Tyr}) |
| Sequence Shortening | Cyclo({d-Asn}-QP-{d-Asn}-S-{(3R)-3-aminotetradecanoic acid}-N-{d-Tyr}) |
| Activity | Fungi; Gram-positive bacteria; Lipopeptide; Antifungal |
| Physical State | Powder |
| Purity | >98% |
| Storage | The power can be stored at 4°C for 2 years or at -20°C for 3 years. |
For Research Use Only.
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