LL-37 (17-32), Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ162)
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LL-37 (17-32) is an ABCG2 inhibitor. LL-37 (17-32) binds to ABCG2, inhibits its transport activity in a non-competitive manner, and downregulates ABCG2 protein expression via lysosomal degradation. LL-37 (17-32) increases the accumulation of Mitoxantrone (HY-13502) in cancer cells overexpressing ABCG2, thereby reversing mitoxantrone resistance. LL-37 (17-32) can be used in the research of multidrug-resistant cancers.
| Overview | |
|---|---|
| Synonyms | LL-37(17-32); LL-37 (17-32); LL-37 fragment 17-32; GF-17 |
| Source | Human |
| CAS | 717919-61-4 |
| Molecular Formula | C95H161N29O21 |
| Molecular Weight | 2045.48 |
| Sequence | Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val |
| Sequence Shortening | FKRIVQRIKDFLRNLV |
| Activity | Gram-positive bacteria; Gram-negative bacteria; Fungi; Virus; HIV; Cancer; Biofilm; LPS; Immunomodulation; Human; Cathelicidin |
| Physical State | Powder |
| Purity | >98% |
| Storage | The power can be stored at 4°C for 2 years or at -20°C for 3 years. |
For Research Use Only.
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