Pap12-6-10, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ93)
Pap12-6-10 is an MD-2 ligand that binds to the hydrophobic pocket of MD-2 to inhibit the dimerization of the TLR4/MD-2 complex and downstream inflammatory signal transduction. Pap12-6-10 also binds to LPS to permeabilize bacterial cell membranes and induce oxidative stress, leading to bacterial death. Pap12-6-10 regulates LPS-induced inflammatory responses through the TLR4 signaling pathway and exhibits antibacterial activity against multidrug-resistant Gram-negative bacteria. Pap12-6-10 shows low tendency to induce drug resistance and low preclinical cytotoxicity, and it prevents organ damage in a mouse model of sepsis. Pap12-6-10 can be used for research related to Gram-negative sepsis and carbapenem-resistant Acinetobacter baumannii infections.
| Overview | |
|---|---|
| Synonyms | Pap12-6-10; Papiliocin derivative |
| Source | Synthetic |
| Sequence | {d-Arg}-{d-Trp}-{d-Lys}-{d-Ala}-{d-Phe}-{d-Lys}-{d-Lys}-{d-Leu}-{d-Leu}-{d-Lys}-{d-Lys}-{ d-Trp}-NH2 |
| Sequence Shortening | rwkafkkllkkw-NH2 |
| Activity | Gram-positive bacteria; Gram-negative bacteria; Fungi; Virus; Cancer cells; Biofilm |
| Physical State | Powder |
| Purity | >98% |
| Storage | The power can be stored at 4°C for 2 years or at -20°C for 3 years. |
For Research Use Only.
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