Retrocyclin-101, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ105)
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Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression.
| Overview | |
|---|---|
| Synonyms | Retrocyclin-101; RC-101; Retrocyclin 101; Retrocyclin-1; θ-defensin analog |
| Source | Not specified |
| Sequence | Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Lys-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg (Disulfide bridg e:Cys3-Cys16;Cys5-Cys14;Cys7-Cys12) |
| Sequence Shortening | GICRCICGKGICRCICGR (Disulfide bridge:Cys3-Cys16;Cys5-Cys14;Cys7-Cys12) |
| Activity | Gram-positive bacteria; Gram-negative bacteria; Fungi; Virus; HIV; Cancer cells; Immunomodulation; LPS |
| Physical State | Powder |
| Purity | >98% |
| Storage | The power can be stored at 4°C for 2 years or at -20°C for 3 years. |
For Research Use Only.
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