Thanatin, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ139)
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Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption.
| Overview | |
|---|---|
| Synonyms | Thanatin; Thanatin peptide |
| Source | Insect |
| CAS | 214542-43-5 |
| Molecular Formula | C103H177N35O27S3 |
| Molecular Weight | 2433.92 |
| Sequence | Gly-Ser-Lys-Lys-Pro-Val-Pro-Ile-Ile-Tyr-Cys-Asn-Arg-Arg-Thr-Gly-Lys-Cys-Gln-Arg-Met ( Disulfide bridge:Cys11-Cys18) |
| Sequence Shortening | GSKKPVPIIYCNRRTGKCQRM (Disulfide bridge:Cys11-Cys18) |
| Activity | Gram-positive bacteria; Gram-negative bacteria; Fungi; Virus; Cancer; Insect; LptA; LPS transport |
| Physical State | Powder |
| Purity | >98% |
| Storage | The power can be stored at 4°C for 2 years or at -20°C for 3 years. |
For Research Use Only.
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