As a global leader in the field of drug discovery, Creative Biolabs offers a series of in vivo PK study services for worldwide customers to enable directed and meaningful preclinical drug discovery and development programs. By leveraging a wealth of experience and advanced technology, now we can provide both standard and customized pharmacokinetics disease models in the most high-quality and cost-effective way for worldwide clients. Our well-trained study directors will work closely with you to ensure your programs a success.

Introduction of Pharmacokinetics Disease Models

Generally, the pharmacokinetic parameters of a new drug are obtained from preclinical researches performed in normal animals or human. And the recommended dose of the drug is also applicable to the general population. However, chronic diseases are associated with pathophysiological changes that could have profound impacts on the pharmacokinetic behavior of drugs, with a potential need to modify the administered drug therapy. In particular, ADME processes of drug candidates in the body will have a certain change. Therefore, it is very important to conduct PK studies in related animal disease models that can incorporate these changes to predict their pharmacokinetic impact.

Concept of physiologically-based pharmacokinetic (PBPK) model as a mathematical representation of the human body, and human-on-a-chip as a physical replication of a PBPK model. Fig.1 Concept of physiologically-based pharmacokinetic (PBPK) model as a mathematical representation of the human body, and human-on-a-chip as a physical replication of a PBPK model. (Sung, et al. 2013)

Pharmacokinetics Disease Models Service Provided by Creative Biolabs

Working in the field of PK studies for many years, Creative Biolabs has developed a series of physiologically based pharmacokinetic disease models to help our worldwide customers clarify disease-related PK parameters changes. Based on a wealth of experience and advanced technology, our professional staffs can perform these studies in both rodents and non-human primates with numerous administration routes, such as oral, intravenous, inhalation, subcutaneous, and intramuscular. Most importantly, we can provide an extensive and broad-based library of animal disease models to accelerate the development of your programs. Examples of PK disease models we can offer including but not limited to:

  • Neurological Disease Models
  • Inflammation & Immunological Disease Models
  • Metabolic Disease Models
  • Digestive System Disease Models
  • Urogenital Disease Models

Our Advantages

  • Personalized: Both standard and custom-built services to meet your specific requirements
  • Comprehensive: Full-scale PK disease models to support clinical trials
  • Quickly: Short duration with advanced technologies
  • Cost-effective: Competitive price with the best quality

Creative Biolabs is committed to being your good partner in new drug discovery. With a wealth of experience, our professional scientists are happy to assist you in selecting the most appropriate PK disease models for your research. Moreover, our scientists and regulatory experts will work closely with you to provide a personalized and comprehensive service to help you gain marketplace advantage.

Except for pharmacokinetics disease model services, we also provide other in vivo PK study services listed below to meet every client’s requirements.

For more details and information, please feel free to contact us and get a quote.

Reference

  1. Sung, et al. "Microfabricated mammalian organ systems and their integration into models of whole animals and humans." Lab on a Chip 13.7 (2013): 1201-1212.

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