As a professional preclinical CRO company, Creative Biolabs provides many kinds of non-human primate (NHP) disease models (please click here to find more information) and has accumulated extensive experience in model utilization and related experiments. With the fully-equipped facilities, a professional R&D team, and the standardization management system, we have assisted our global clients and advanced their preclinical non-GLP projects on our pharmacology and pharmacodynamics (PD/PK) platform.
Spontaneous obesity refers to the excessive amount of adipose tissue in the body or the ratio of adipose tissue higher than that of other soft tissues. It is often accompanied by obstacles in the regulation of glucose metabolism. Spontaneous obesity is considered related to a high risk of cardiovascular disease and diabetes. The incidence of diabetes in obese people is about 10 times that of non-obese people. In addition, the morbidity and mortality of malignant tumors in humans with spontaneous obesity are relatively higher than those of normal humans.
Spontaneous obesity animal models are usually characterized by increased food intake, hyperlipidemia, hyperinsulinemia, insulin resistance, and low metabolic rate. Spontaneous obesity animal models are mainly genetically obese rodents, including ob/ob mice, db/db mice, KK-Ay mice, Zucker rats, and LA/N obese rats. Moreover, spontaneous obesity is often reported in NHPs, especially rhesus monkeys (Macaca mulatta), cynomolgus monkeys (Macaca fascicularis), vervet monkeys (Chlorocebus aethiops), and Janpanese monkeys (Macaca fuscata). NHP has obesity-related physiological changes very similar to humans, making NHP a valuable research model for obesity.
Compared with humans, spontaneous obesity in NHPs occurs in a shorter time frame, which can greatly shorten the research period. While compared with rodent models, spontaneous obesity in NHPs occurs in a longer time frame, which can provide researchers with a long enough research period to fully study the pathogenesis. Importantly, the menstrual cycle of female Old World primates is very close to that of humans. Therefore, female monkeys provide a useful model for studying reproductive aging, menopause, and hormonal imbalances and their association with an increased risk of spontaneous obesity.
Fig.1 Intraperitoneal glucose tolerance test (iPGTT) in a marmoset model of obesity. (Weiss, et al., 2021)
With much experience in the NHP disease model establishment, Creative Biolabs provides the well-established obesity model in NHPs. Moreover, we provide related analysis services including blood sampling and biochemical tests, intraperitoneal glucose tolerance test (iPGTT), brachial artery FMD measurement, percent body fat analysis, glucose-stimulated insulin secretion (GSIS) assay, α-cell mass, and β-cell mass examination, islet vascularization, somatostatin, and pancreatic polypeptide (PP) analysis, etc. to assist you in your preclinical drug efficiency evaluation.
If you are interested in the NHP models of obesity or have any questions about the model utilization, please feel free to contact us for further discussions. The scientists of Creative Biolabs will work closely with you, and provide you with reasonable study design and scientific solutions for your study project. We are your trustworthy CRO partner.
Creative Biolabs offers various Metabolic Disorder Models you may be interested in:
| Metabolic Disorder Models | |
| Type I Diabetes Model | Type II Diabetes Model |
| Diet-Induced Obesity (DIO) Model | Primate Spontaneous Obesity Model |
| Primate Dyslipidemia Model | |
Reference
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