Creative Biolabs now provides the well-established renal disease models according to specific custom needs. In combination with state-of-the-art technologies and our seasoned team of experts, we guarantee our global clients the most reliable service at the most competitive price. Our all-around animal study services have benefited numerous preclinical research programs, providing solid data confidence for our clients during IND submission.

What is renal disease?

Kidneys are one of the most critical body organs that play a vital role in many biophysical processes such as filtering waste products, regulating blood pressure, electrolyte balance, and red blood cell production. Renal disease (also known as kidney disease), represent a broad class of diseases caused by damages/abnormalities of the kidney, which can elicit many severe clinical symptoms.

Renal Disease Models

The important role of non-human primates (NHPs) models in renal disease

Biological studies have revealed a lot of similarities between non-human primates (NHPs) and human beings. For this reason, non-human primates are constituting an indispensable part of biomedical research discovering the causes, progression of a wide range of human diseases, as well as evaluating in vivo characteristics of new drugs/treatments.

Typical renal disease models provided by Creative Biolabs

Acute renal failure (ARF) is a rapid onset disease characterized by the loss of the kidney's excretory function and is typically diagnosed by the accumulation of end products of nitrogen metabolism (creatinine and urea) and/or decreased urine output. Currently, ARF models can be divided into ischemic-induced models, drug-induced models (e.g. cisplatin, NSAIDs, gentamicin, and cysplatin), sepsis-induced models as well as others.

Chronic renal failure (CRF) is commonly considered as the progressive loss of kidney function. CRF can be induced by surgical procedures, freezing, electric coagulation, or infusions of drugs/substances, etc.

Renal hypertension (RH) is a pathological condition characterized by high blood pressure due to the kidneys' hormonal response which narrows the arteries supplying the kidneys. Renovascular hypertension can be induced by various methods, such as Goldblatt method, external compression of renal parenchyma, coarctation of the aorta, reduced renal mass, and glomerular sclerosis secondary to microsphere embolization. We provide customized RH modeling service mainly based on Goldblatt method.

Renal Disease Models

Of note, we also present a comprehensive portfolio of endpoint/QC measurements including:

  • Complete blood count (CBC)
  • Serum biochemistries (e.g. creatinine, urea nitrogen)
  • Urine electrolytes
  • Urine analysis with microscopy
  • Histology for infarct

Creative Biolabs is proud to offer featured service based on our renal disease NHP models. Our expertise also covers neurological disease, cardiovascular and metabolic disorders, liver disease, urogenital disease, immune disease, etc. To ensure a smooth and successful completion of your project, a Ph.D. technical support will be assigned to your project from initial inquiry to post-delivery. Please feel free to contact us for more information.

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