As one of the leading-edge experts among the frontier of NHP model building service, Creative Biolabs now Rheumatoid Arthritis (RA) Model offers featured rheumatoid arthritis (RA) NHP model for customers all over the world. Based on unparalleled technique platforms and seasoned team of experts, we guarantee our clients the most reliable and efficient research services to best deliver their research goal.

What is rheumatoid arthritis?

Rheumatoid arthritis (RA) is one of the most common autoimmune disorders which can cause chronic inflammation in multiple joints (or arthrosis). Over time, cartilage will be lost gradually, and the joint spacing between bones can become smaller. Joints will be loose, unstable, painful and lose their mobility. Joint deformity also can occur. The primary and most obvious symptom of this disease is warm, swollen, and painful joints. RA is majorly caused by immune system dysfunction when one's immune system mistakenly attacks normal tissues.

Advantages of non-human primates (NHPs) models

Rheumatoid Arthritis (RA) Model

Laboratory animals are valuable tools to study the disease pathophysiology and to evaluate/validate therapeutic reagents/devices. Rodent models (e.g. rats and mice) represent the most widely used objects in this regard. However, the evolutionary distance between rodents and humans hinders the translation of experiment outcomes into real human trials. Non-human primates (NHPs), on the other hand, are known to highly resemble humans in terms of anatomical, genetic, microbiological, physiological, and immunological characteristics. Therefore, NHPs can help to bridge the huge gap between inbred rodent strain models and the heterogeneous RA patient population. 

RA models provided by Creative Biolabs

Unlike successful RA modeling in rodents, NHP RA model has been reported to be extremely difficult due to the low and inconsistent disease incidence in both cynomolgus macaques and rhesus macaques. After years of exploration, scientists in Creative Biolabs now can successfully induce RA in cynomolgus monkeys using type II collagen. This well-characterized NHP arthritis model has proved good utility in rheumatology studies, inflammation related anemia and pain studies. We also provide a full set of evaluation and validation measures, including:

  • Body weight
  • Primary endpoints for evaluating arthritis
  • Disease incidence
  • Arthritic incidence of proximal interphalangeal joints
  • Measurement of joint swelling
  • Arthritic score

Based on advanced technology platforms and specialized expertise, Creative Biolabs is glad to serve our global clients with high-quality NHP modeling service. Besides immune system disorders, we also offer hundreds of alternative disease models, e.g. neurological disease, cardiovascular and metabolic disorders, liver disease, urogenital disease, and renal disease. Our scientists are confident in tailoring our customers the most reliable and well-characterized NHP models to facilitate their cutting-edge research. Please feel free to contact us for further discussions.

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