Creative Biolabs is a world-leading provider of first-class spinal cord injury (SCI) NHP models. We have successfully established a full range of SCI models based on customers' requirements. Our experienced NHP scientists are very pleased to help clients and facilitate their preclinical research programs.

What is neuroscience?

Neuroscience focus on studying the structural, cellular, molecular, functional, evolutionary, psychosocial, medical and computational aspects of the central and peripheral nervous system. Extensive research in neuroscience promote understanding of neurological disorder (e.g. Parkinson's disease, middle cerebral artery occlusion, cerebral infarction, and cerebral stroke) and facilitate developing more effective therapeutic regimens.

Spinal Cord Injury (SCI) Model

The advantages of non-human primates (NHPs)

Non-human primates (NHPs) highly mimic humans in many aspects including genomics, neurophysiology, neuroanatomy, and immunogenetics, etc. More importantly, they have similar neural circuitry to humans that make them more accurate and valuable models of neurological diseases in comparison to other animals.

What is spinal cord injury (SCI)?

The spinal cord is composed of a tubular bundle of nervous tissue and support cells. It starts from the medulla oblongata in the brainstem to the lumbar region of the vertebral column. The spinal cord is in charge of signal transduction to other regions of the body from the brain. A spinal cord injury (SCI) is damage to the spinal cord that alters its function temporarily or permanently. Generally, SCI can result in loss of muscle function, autonomic function or sensation in parts of the body all the way down the lesion part.

Spinal Cord Injury (SCI) Model

SCI models provided by Creative Biolabs

SCI models can be classified into 6 categories based on the mechanism of injury including compression, contusion, distraction, transection, dislocation, and chemical models. Compression devices compress the cord to cause SCI at given force and duration. Contusion devices often using an air pressure, electromagnetic impactor or weight-drop technique to inflict an acute, transient injury to the spinal cord. Distraction SCI devices are able to inflict graded injury by controlled stretching of the cord. Mechanical displacement of the vertebrae is generally used to produce dislocation-type SCI. Surgical transection of the cord is particularly useful in regenerative medicine. Finally, select components of the secondary injury cascade can be replicated by chemically induced SCI.

Creative Biolabs is capable of providing different kinds of SCI NHP models based on clients' needs. Our comprehensive assessment package including but not limited to:

  • Motor-evoked potential (MEP)
  • Somatosensory-evoked potential (SSEP)
  • MR imaging
  • Monkey hindlimb score (MHS)

Creative Biolabs is professional in building different NHP models (e.g. renal disease, cardiovascular and metabolic disorders, liver disease, urogenital disease, and immune disease). Please feel free to contact us for more details.

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