With years of experience in toxicology study, Creative Biolabs is capable of providing standard vaginal mucosal irritation test for our worldwide customers in compliance with GLP regulation. During the past years, we have set up several state-of-the-art preclinical experimental platforms and successfully completed many toxicology study programs. It is our long-term promise to deliver the most high-quality and cost-effective service to accelerate our client's programs development.
Importance of Vaginal Mucosal Irritation Test
Vaginal mucosa, as one of the body's hosts defense and immune surveillance components, is a natural barrier that is constantly exposed to bacteria and viruses. However, the vaginal epithelium can be damaged mechanically, e.g. by the incorrect use of objects such as tampons, or by chemicals that are irritating or corrosive. Consequently, this can make the tissues more susceptible to infections. Therefore, it is essential to predict the effects of personal care, cosmetic and pharmaceutical products for vaginal use on humans before the product is marketed.
Introduction of Vaginal Mucosal Irritation Test
For a long time, the rabbit vaginal irritation test (RVI) has been the most frequently used method for assessing vaginal mucosal irritation. Although the vaginal tissues between rabbit and human are dissimilar, the rabbit method is still preferred and widely used to determine the vaginal tolerance or mildness of topical spermicidal preparations. While, in recent years, the concept of the 3Rs (refinement, replacement, and reduction) has stimulated the development of alternative in vitro methods. Various in vitro studies, such as cell lines and reconstituted tissue models, have been confirmed that they have the potential to replace the RVI model when used for cosmetic and personal care product screening.
Vaginal Mucosal Irritation Services Provided by Creative Biolabs
With a wealth of experience and advanced technology, Creative Biolabs has the ability to offer both standard and alternative methods for the assessment of vaginal irritation. The service we can provide followed as below:
You may also be interested in other local toxicity studies:
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Moreover, Creative Biolabs can provide other standard and customized toxicology study services to meet every client's requirements. If you are interested in the service we provide, please click the links below.
We are happy to be with you at every step in your new drug development process. For more detailed information, please feel free to contact us or directly sent us an inquiry.
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