Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Endothelin receptor type A |
| Gene Name | EDNRA |
| Uniprot | P25101 (Human); Q61614 (Mouse) |
| Synonym | ETA; ET-A; ETAR; ETRA; MFDA; ETA-R; hET-AR; endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor |
| Background | EDNRA (endothelin receptor type A), also referred as ETA, is a member of the receptor group for endothelin-1 belonging to the G protein-coupled receptor in human and encoded by EDNRA gene. Polymorphisms in this gene are associated with migraine headache resistance. EDNRA is a peptide that plays a role in potent and long-lasting vasoconstriction and cell proliferation. This receptor binds to guanine-nucleotide-binding (G) proteins, and this coupling results in the activation of a phosphatidylinositol-calcium second messenger system. It has been suggested that EDNRA can interact with HDAC7A and HTATIP. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX279 | NativeExtract™ Human EDNRA Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0622-KX75 | MemDX™ Recombinant Human EDNRA Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPX0947K | MemDX™ Membrane Protein Human EDNRA Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0318X | MemDX™ Membrane Protein Human EDNRA (Endothelin receptor type A) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0317X | MemDX™ Membrane Protein Human EDNRA (Endothelin receptor type A) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
Ze***r: Creative Biolabs has been a game-changer for our research team.
23/Jul/2023
K***os: The product quality is top-notch, and it has significantly accelerated our research progress. I can't thank Creative Biolabs enough for their excellent service and dedication to customer satisfaction.
07/Apr/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
siRNA and shRNA
Creative Biolabs offers siRNA and shRNA development services. Harnessing the intricate mechanisms of post-transcriptional gene regulation, small interfering RNA (siRNA) and short hairpin RNA (shRNA) stand as potent tools for precisely attenuating specific gene expression, exemplified by their utility in downregulating the EDNRA gene. These meticulously engineered nucleic acid constructs are designed to engage with and subsequently trigger the degradation of complementary EDNRA mRNA transcripts. Consequently, this targeted intervention effectively diminishes the cellular abundance of the corresponding EDNRA protein, offering a sophisticated approach to modulating its biological functions.
mRNA Therapy
Creative Biolabs offers mRNA therapy development services. The delivery of synthetic mRNA, engineered to encode a functional EDNRA protein, offers a compelling strategy for reconstituting its expression within cellular systems. This innovative molecular approach circumvents the necessity for direct genomic integration, a common concern with certain gene therapy modalities, thereby potentially mitigating associated risks. Consequently, this method is posited to afford a therapeutic effect that, while perhaps transient in nature, can nonetheless be remarkably efficacious in restoring EDNRA protein levels and, by extension, its crucial biological activity.
Antisense Oligonucleotides (ASOs)
Creative Biolabs offers ASOs development services. ASOs characterized by their sequence-specific design, represent a sophisticated molecular strategy for influencing gene expression. These meticulously engineered nucleic acid constructs are formulated to hybridize with target EDNRA mRNA transcripts. Such binding subsequently facilitates precise regulation over either the transcript's processing, by modulating its splicing patterns, or its overall cellular persistence, by altering its stability and degradation kinetics. Consequently, this methodology proves particularly efficacious in addressing discrete genetic alterations or distinct splice variants of the EDNRA gene, thereby offering a highly tailored approach to therapeutic intervention.
Creative Biolabs offers comprehensive and innovative services to drive the development of EDNRA cell therapy. Please for more services.
Cell Proliferation Assays
Creative Biolabs offers cell proliferation assay services. The CCK-8 assay constitutes a widely adopted, colorimetric methodology for the robust quantification of cellular viability and proliferative capacity. Typically, adherent or suspension cells are initially cultured by being precisely dispensed into multi-well microplates, most commonly those configured with 96 wells, establishing the experimental replicates. Subsequently, the proprietary CCK-8 reagent is introduced into each culture well. This compound undergoes enzymatic reduction by cellular dehydrogenases present in metabolically active cells, thereby generating a soluble formazan dye with a characteristic yellow hue.
Wound Healing Assays
Creative Biolabs offers wound healing assay services. Such experimental methodologies are instrumental in quantitatively assessing cellular migratory capabilities. Cells are meticulously seeded within six-well culture plates, establishing a confluent monolayer. Subsequently, a standardized mechanical wound is deliberately introduced into this monolayer, typically via a sterile pipette tip, thereby generating a defined cell-free gap. The dynamic process of cellular translocation into this created void is then longitudinally monitored through time-lapse microscopy, with images systematically captured over a specified duration. The ensuing analysis, leveraging specialized image processing software, precisely quantifies the migratory displacement, providing an objective measure of cell motility.
Immune Infiltration Analysis
Creative Biolabs offers immune infiltration analysis services. Single-sample gene set enrichment analysis constitutes a robust computational methodology, widely employed for the systematic deconvolution and quantitative assessment of the relative infiltration levels of diverse immune cell populations within heterogeneous biological specimens. This powerful analytical framework facilitates the extraction of granular insights into the immunological landscape inherent to a given sample. Subsequently, this detailed quantification of immune cell presence permits the rigorous investigation of potential correlative relationships. Such analyses might precisely delineate the association, or perhaps the lack thereof, between these empirically derived immune cell infiltration metrics and the transcriptional profile of specific genes, thereby offering a nuanced understanding of immunomodulatory influences on gene activity.
Over years Creative Biolabs has successfully generated many functional membrane proteins for our customers. We are happy to tailor one-stop, custom-oriented service packages regarding a variety of membrane protein targets. Please feel free to for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
