Introduction of EDNRA
EDNRA (endothelin receptor type A), also referred as ETA, is a member of the receptor group for endothelin-1 belonging to the G protein-coupled receptor in human and encoded by EDNRA gene. Polymorphisms in this gene are associated with migraine headache resistance. EDNRA is a peptide that plays a role in potent and long-lasting vasoconstriction and cell proliferation. This receptor binds to guanine-nucleotide-binding (G) proteins, and this coupling results in the activation of a phosphatidylinositol-calcium second messenger system. It has been suggested that EDNRA can interact with HDAC7A and HTATIP.
|Basic Information of EDNRA|
|Protein Name||Endothelin Receptor Type A|
|Aliases||ETA, ET-A, ETAR, ETRA, MFDA, ETA-R, hET-AR|
|Organism||Homo sapiens (Human)|
Function of EDNRA Membrane Protein
EDNRA polymorphism is protective against generalized type of vitiligo and associated diseases. EDNRA is involved in melanocyte functions. By association with G proteins, EDNRA mediates its action that activates a phosphatidylinositol-calcium second messenger system. It was reported that EDNRA was associated with diseases including mandibulofacial dysostosis with alopecia and migraine with or without aura 1. High expression of EDNRA is associated with metastasis and poor outcome in patients with advanced bladder cancer. The prognostic value of EDNRA was successfully validated in an independent patient cohort using tissue microarrays (TMAs).
Fig.1 Scheme illustrating the possible role of Gq/G11-dependent and -independent Edn1/Ednra signaling in pharyngeal arch development.
Application of EDNRA Membrane Protein in Literature
This article reports that VIP potently acts against the airway and pulmonary vascular constriction mediated by endothelin-1, while the ETA and ETB blockers exert a differential effect between airway resistance and PVR.
This article reveals that the hypothesis that the antiproteinuric effect of endothelin antagonism may be translated into a slower progression of diabetic nephropathy.
Endothelin receptor antagonists were considered to be used for the treatment of some diseases like hypertension, diabetes and chronic kidney disease. However, besides pulmonary hypertension, this class is not in clinical use because of the side effects and the availability of safer drugs for the treatment of these diseases.
This article focuses on a difference in ETAR and ETBR expression among TLC, NTLC, and NCLF: the ETAR/ETBR ratio is increased in TLC due to a relative decrease in ETBR expression. This finding may be useful for the diagnosis of TLC with regard to circulatory disturbances in the liver.
This article shows that ETs regulate the catecholaminergic activity and contribute to the right OB to DOCA-salt hypertension.
EDNRA Preparation Options
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