Close

Endothelin Receptor Family

The endothelin receptors are members of the family A G protein-coupled receptors, a class of proteins that has been exploited very successfully as targets for the development of drugs. Currently, there are two endothelin receptors what are now known as the ETA and ETB receptors which are expressed by a wide variety of cells and tissues. They are classified on the basis of their rank order of potencies for the endothelins. Studies have shown that the amino acid sequences deduced from cloned ETA and ETB receptors predict that these receptors are heptahelical G-protein coupled receptors. In humans, the ETA receptor is predicted to be 427 amino acids long and shows approximately 64% sequence similarity to the predicted 442 amino acid long human ETB receptor. During the past years, numerous functions and applications of the endothelin receptor family have been widely studied.

Here, we give a comprehensive introduction for members of the ET receptor family, including endothelin-1 receptor and endothelin receptor type B. To learn more detailed information, please click the links below.

Human ET Receptor Members
EDNRA EDNRB

Aided by our advanced Magic™ membrane protein production platform, Creative Biolabs is confident in offering diverse target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.

Endothelin Receptor Family

Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2024 Creative Biolabs. | Contact Us