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Enterovirus 71 (EV71) Virus-Like Particles (VLPs)

Creative Biolabs is a global leading service provider of first-class enterovirus 71 (EV71) VLP products. With years of exploration and practice, our team has established the multiple elegant platforms for VLP construction, purification, and characterization. We are more than willing to assist our worldwide clients using our high-quality VLP products/services. Currently, we can offer a full range of VLPs products (e.g. HBV VLP, HIV VLP, HPV VLP, CA16 VLP, poliovirus VLP, polyomaviruses VLP, AAV VLP, bacteriophage Qβ VLP, Zika VLP, etc.).

Virus-like particles (VLPs) is composed of non-infectious empty viral capsids. These particles resemble their corresponding authentic virus from but lack viral nucleic acid, thus are not infectious in any conditions. In virtue of this special feature, VLPs have been widely applied in a variety of areas such as vaccines, antibody development, lipoparticle technology, delivery systems, bioimaging and cell targeting.These empty capsids can be manufactured in:


EV71 virions characterized by negative staining under TEM. Scale bar = 50 nm. Figure 1. EV71 virions characterized by negative staining under TEM. Scale bar = 50 nm. (Vaccine, 2012)

EV71 belongs to the Picornaviridae family. Enteroviruses are divided into two classes, polioviruses and nonpolioviruses. EV71 is defined as a nonpoliovirus. EV71 is one of the common causes of hand-foot-and-mouth disease (HFMD). More severe symptoms can occur if infected, such as aseptic meningitis, encephalitis, and acute flaccid paralysis. Direct contact of discharge from throat, nose, saliva, and blisters or stools of an infected person is the main pathway for EV71 transmission.

EV71 is a symmetrically spherical icosahedral structure envelope and spikes with a diameter about 24-30 nm. The viral nucleic acid is single-stranded positive RNA, and its capsid is composed of 60 subunits. The capsid is a pentamer-like structure consist of four types of capsid proteins (VP1-VP4). VP1-VP3 are exposed on the surface of the viral particle while VP4 is embedded inside the capsid of viral particles and closely attached to the viral core. Therefore, the antigenic determination is mainly based on VP1-VP3.

EV71 VLPs can be typically used for:


Creative Biolabs now provides the most comprehensive VLPs services/products for customers all over the world. Integrated with multiple state-of-the-art technical platforms, we guarantee our clients with the most efficient and reliable service. Our scientists are dedicated to solving challenging problems and satisfying every specific demand from our global clients. Please feel free to inquire us for further discussions.

References

  1. Wang X, Xiao X, Zhao M, et al. (2016). EV71 virus-like particles produced by co-expression of capsid proteins in yeast cells elicit humoral protective response against EV71 lethal challenge. BMC research notes, 9(1), 42.
  2. Lin Y L, Yu C I, Hu Y C, et al. (2012). Enterovirus type 71 neutralizing antibodies in the serum of macaque monkeys immunized with EV71 virus-like particles. Vaccine, 30(7), 1305-1312.



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