Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe feline leukemia virus subgroup C receptor (FLVCR) family, which belongs to the facilitator superfamily of transporter proteins, is the cell surface receptor for leukemia virus, subgroup C. FLVCR family includes two heme export proteins, FLVCR1 and FLVCR2. FLVCR1 is expressed in all hematopoietic tissues including peripheral blood lymphocytes, and also in pancreas and kidney. On the contrary, FLVCR2 is primarily found in non-hematopoietic tissues, with relative abundant expression in brain, placenta, lung, liver, and kidney. FLVCR2 is also found in hematopoietic tissues, such as fetal liver, spleen, lymph node, thymus, leukocytes and bone marrow. FLVCR family is a group of heme export protein that is required for proerythroblast survival and facilitates macrophage heme iron recycling. Furthermore, studies of FLVCR expression in cell lines suggest this exporter also impacts heme trafficking in intestine and liver.
Studies have shown that the export of heme via FLVCR is tightly regulated by the presence and avidity of the extracellular heme-binding proteins hemopexin and albumin. Above all, heme export by FLVCR is a mechanism for heme iron trafficking to prevent cellular heme and iron toxicity and to maintain heme and iron homeostasis. Here, we have given further information on the two members of FLVCR family.
Owing to our state-of-the-art MemDX™ membrane protein production platform, scientists in Creative Biolabs are ready to offer the preparation of these two membrane proteins in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Moreover, our MemDX™ membrane protein antibody discovery platform can be applied in developing antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
