Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Free fatty acid receptor 1 |
| Gene Name | FFAR1 |
| Uniprot | O14842 (Human); Q76JU9 (Mouse) |
| Synonym | FFA1R; GPR40; GPCR40; G-protein coupled receptor 40 |
| Background | FFAR1, also known as FFA1R or G-protein coupled receptor 40 (GPR40), is an approximately 31.5 kDa G-protein coupled receptor (GPCR) that has 300 amino acids length. In humans, this protein is encoded by the FFAR1 gene mapping at the cytogenetic band of chromosome 19q13.12. It belongs to the GP40 family of G protein-coupled receptors that plays an important role in glucose homeostasis. Free fatty acid (FFA) receptors are a group of Gq/11 protein-coupled receptors recently classified into four subtypes of FFA1, FFA2, FFA3, and FFA4. FFA receptors, essential for immunity and metabolism, are known to be concentrated in pancreatic islet cells and immune cell, as well as in the brain. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX362 | NativeExtract™ Human FFAR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX2930K | MemDX™ Membrane Protein Human FFAR1 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
L***a: Their team was highly professional and knowledgeable. They provided detailed updates throughout the process and delivered the final products ahead of schedule.
22/Apr/2023
R***rt: Creative Biolabs has been a great partner for our research. We were particularly impressed with their expertise in protein engineering.
09/Jan/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers base editing services. The emergence of base editing technologies has significantly recalibrated the landscape of genetic manipulation. This innovative class of molecular tools facilitates the direct interconversion of one nucleotide base pair into another, circumventing the introduction of potentially deleterious double-strand breaks within the genomic architecture. Perhaps the most compelling application of this methodology lies in its capacity for highly localized genomic rectification. Specifically, within the context of the FFAR1 gene, base editing offers a precise avenue for the amelioration of pathogenic sequence variations. Consequently, this approach represents a notable departure from conventional gene editing paradigms, offering a potentially safer and demonstrably more precise strategy for the targeted modification of the FFAR1 locus.
Creative Biolabs offers AAV vectors development services. AAV vectors have emerged as a cornerstone in the expanding repertoire of gene therapeutic strategies. Their widespread adoption is largely attributable to an advantageous safety profile coupled with their documented capacity for stable, albeit predominantly episomal, persistence within the host cellular milieu. These naturally occurring viral entities possess an inherent ability to be genetically manipulated, enabling the precise insertion of exogenous genetic material. Consequently, AAV platforms can be engineered to harbor and subsequently deliver a fully functional cDNA sequence corresponding to the FFAR1 gene into designated recipient cells.
Creative Biolabs offers lentiviral vectors services. Lentiviral vectors represent another prominent class of viral delivery systems employed in contemporary gene therapy. These sophisticated vectors are distinguished by their substantial cargo capacity, a feature that facilitates the packaging and transfer of larger genetic sequences. Critically, lentiviruses possess the inherent enzymatic machinery required for stable integration of their genetic payload directly into the host cell's genome. This chromosomal integration is pivotal, as it generally ensures robust and enduring expression of the therapeutic transgene within the target cell population.
Creative Biolabs offers comprehensive and innovative services to drive the development of FFAR1 cell therapy. Please for more services.
Creative Biolabs offers insulin secretion assay services. Given the pivotal involvement of FFAR1 in the intricate physiological process of glucose-stimulated insulin secretion (GSIS), the rigorous evaluation of prospective FFAR1 agonists becomes an indispensable component of cell therapy discovery initiatives. This critical assessment typically involves probing the pharmacodynamics of these compounds on insulin-secreting cellular models. Specifically, investigations often converge on pancreatic beta-cells, the primary cellular architects of insulin production and release within the islets of Langerhans. By precisely quantifying the insulin output in response to varied chemical entities, researchers can systematically discern agents capable of potentiating insulin secretion. Such an approach holds considerable promise for identifying novel therapeutic candidates that might, perhaps, ameliorate glucose dysregulation.
Creative Biolabs offers stable cell line development services. The generation of stable cell lines constitutively expressing FFAR1 is a fundamental prerequisite for advancing our comprehension of this crucial receptor and for the systematic identification of novel therapeutic agents. Such engineered cellular systems offer an indispensable, reproducible, and consistent platform for in-depth investigations into FFAR1's biological function. These bespoke cell lines are invaluable assets in high-throughput drug screening initiatives, facilitating the rapid assessment of numerous compounds for their agonistic or antagonistic effects. Consider the HEK293 cell line, for example; when engineered to stably express FFAR1, it becomes a powerful tool for dissecting the precise impact of various ligands on receptor-mediated intracellular signaling.
Creative Biolabs offers primary cell development services. While established cell lines offer a consistent and reproducible system for initial investigations, the utilization of primary cells is paramount for attaining physiologically relevant insights into the multifaceted roles of FFAR1 across diverse tissue contexts. These unmanipulated cells, directly isolated from either animal models or human donors, retain the intricate cellular architecture and signaling nuances often lost in continuous cell cultures. Consequently, they furnish a more native biological environment for assessing the pharmacodynamics of compounds engineered to target FFAR1.
Creative Biolabs as a world-class researcher and a leading custom service provider in the market of membrane proteins has won a high reputation among worldwide customers for successfully accomplishing various challenging projects. Recently, we are introducing our professional membrane protein preparation services in required formats with many different options. Please feel free to for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
