Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Free fatty acid receptor 2 |
| Gene Name | FFAR2 |
| Uniprot | O15552 (Human); Q8VCK6 (Mouse) |
| Synonym | FFA2R; GPR43; G-protein coupled receptor 43; fatty acid receptor 2; free fatty acid activated receptor 2 |
| Background | FFAR2, also known as FFA2, G-protein coupled receptor 43 (GPR43) or GPCR43, is a 37 kDa G-protein coupled receptor (GPCR) that has 330 amino acids, encoded by the gene mapping at the chromosome 19q13.12. It is a dual-coupling receptor that is coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family proteins. FFAR2 has been studied to participate in a number of biological activities. It can be activated by short-chain fatty acids (SCFAs) that include acetate, propionate, and butyrate. SCFAs act as a source of energy and also serve as signaling molecules. FFAR2 and other free fatty acid (FFA) receptors are regarded as key constituents of the nutrient sensing mechanism and targeting FFA receptors are assumed to provide novel therapies for the management of metabolic disorders, such as diabetes. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX277 | NativeExtract™ Human FFAR2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3348K | MemDX™ Membrane Protein Human FFAR2 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0465X | MemDX™ Membrane Protein Human FFAR2 for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0364X | MemDX™ Membrane Protein Human FFAR2 (Free fatty acid receptor 2) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
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Creative Biolabs offers gene editing services for FFAR2 transcriptional modulation. The integration of gene editing systems enables precise modulation of FFAR2 expression, a G protein-coupled receptor pivotal in mediating short-chain fatty acid (SCFA) signaling. For instance, allele-specific editing in intestinal epithelial cells has been employed to correct FFAR2 loss-of-function mutations associated with impaired anti-inflammatory responses. Creative Biolabs' proprietary RNA design algorithms enhance specificity, minimizing off-target effects—an essential consideration for translational applications. Such methodologies hold promise for addressing dysbiosis-linked pathologies, including inflammatory bowel disease (IBD) and metabolic syndrome.
Creative Biolabs offers AAV-mediated FFAR2 gene delivery services. Adeno-associated virus (AAV) vectors engineered with tissue-specific promoters enable localized FFAR2 overexpression in organs such as the pancreas or adipose tissue. Preclinical studies demonstrate that intraperitoneal delivery of AAV9-FFAR2 constructs enhances insulin sensitivity in diabetic models by amplifying SCFA-induced glucagon-like peptide-1 (GLP-1) secretion. Creative Biolabs' expertise in capsid optimization ensures efficient tropism for visceral tissues while circumventing immune clearance. This approach may synergize with existing therapies for type 2 diabetes, offering a combinatorial strategy to restore metabolic homeostasis.
Creative Biolabs offers siRNA knockdown services for FFAR2 signaling attenuation. In hyperinflammatory states, transient suppression of FFAR2 via lipid nanoparticle-encapsulated siRNA can mitigate excessive neutrophil activation. Leveraging Creative Biolabs' high-throughput screening platforms identified siRNA sequences with >90% silencing efficiency in myeloid cells. This strategy is particularly relevant for acute conditions such as sepsis, where FFAR2-driven cytokine storms exacerbate tissue damage. Customizable delivery systems ensure temporal control, aligning therapeutic intervention with disease progression dynamics.
Creative Biolabs offers comprehensive and innovative services to drive the development of FFAR2 cell therapy. Please for more services.
Creative Biolabs offers CAR-macrophage engineering services. Chimeric antigen receptor (CAR) macrophages engineered to overexpress FFAR2 exhibit enhanced phagocytic activity and anti-inflammatory cytokine secretion in response to SCFAs. Creative Biolabs' lentiviral transduction protocols enable stable FFAR2 integration, yielding cells capable of homing to atherosclerotic plaques or tumor microenvironments. Preclinical data indicate that these "smart" macrophages reduce plaque necrosis in cardiovascular models while polarizing tumor-associated macrophages toward an M1 phenotype—a dual mechanism with broad therapeutic potential.
Creative Biolabs offers iPSC-derived FFAR2+ enteroendocrine cells development services. iPSCs differentiated into FFAR2-positive enteroendocrine cells offer a renewable source for cell replacement therapies in diabetes. By activating FFAR2 via SCFAs, these cells secrete GLP-1 and peptide YY (PYY), restoring glycemic control and satiety signaling. Creative Biolabs' differentiation kits achieve >85% purity, critical for minimizing off-target hormone release. Encapsulation devices compatible with these cells are under development, aiming for long-term engraftment in the gastrointestinal lumen without immunosuppression.
Creative Biolabs offers ex vivo FFAR2 priming in dendritic cell vaccine development services. Dendritic cells (DCs) pre-treated with FFAR2 agonists ex vivo exhibit enhanced tolerogenic properties, making them ideal for applications in autoimmune diseases. Creative Biolabs' protocols ensure consistent activation of FFAR2 signaling pathways, which upregulate IL-10 production while suppressing IL-12. In murine multiple sclerosis models, these DCs significantly delayed disease onset, underscoring their potential as a first-in-class tolerogenic vaccine platform.
The convergence of gene and cell therapy technologies opens unprecedented avenues for targeting FFAR2 in metabolic, inflammatory, and oncological disorders. Creative Biolabs' cross-disciplinary expertise ensures that your program benefits from cutting-edge tools, including customizable viral vectors, gene editing libraries, and clinically relevant cell models. to initiate a project scoping session—your innovation, accelerated by our execution.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
