Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Formyl peptide receptor 1 |
| Gene Name | FPR1 |
| Uniprot | P21462 (Human); P33766 (Mouse) |
| Synonym | FPR; FMLP; fMet-Leu-Phe receptor; N-formylpeptide chemoattractant receptor; fMLP receptor |
| Background | FPR1, also referred to formyl peptide receptor 1, fMet-Leu-Phe receptor (fMLP receptor), N-formyl peptide receptor or N-formylpeptide chemoattractant receptor, is a 38.4 kDa cell surface receptor protein that belongs to the family of G protein-coupled pattern recognition receptors. In humans, this gene is located at the chromosome 19q13.41 and encodes a 350 amino acids protein. FPR1 is predominantly expressed on mammalian phagocytic leukocytes and is a key player in the host defense and innate immunity. This protein is a high-affinity receptor for fMLP, a powerful neutrophil chemotactic factor. Binding of fMLP to FPR1 receptor can stimulate intracellular calcium mobilization, together with superoxide anion release. This process is mediated by a G-protein which activates the phosphatidylinositol-calcium second messenger system. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX274 | NativeExtract™ Human FPR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3420K | MemDX™ Membrane Protein Human FPR1 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0376X | MemDX™ Membrane Protein Human FPR1 (Formyl peptide receptor 1) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0375X | MemDX™ Membrane Protein Human FPR1 (Formyl peptide receptor 1) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| MPX4314K | MemDX™ Membrane Protein Human FPR1 Expressed in E.coli with 10xHis and GST tag at the N-terminus, Myc tag at the C-terminus, Partial (306-350aa) | E.coli | Partial | N/A |
| Please for more products or customization | ||||
F**n: Their tailored FPR1 service delivered a soluble, His-tagged construct.
07/Mar/2023
K**x: Accelerated timelines met urgent project needs without compromising functional validation results.
03/Nov/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers gene editing services. Gene editing technology offers unparalleled precision in modifying the FPR1 locus to address gain- or loss-of-function mutations implicated in inflammatory and oncogenic pathways. For instance, allelic-specific knockout of hyperactive FPR1 variants in myeloid cell lines has been shown to attenuate pro-inflammatory cytokine release, a strategy with therapeutic relevance for chronic inflammation. Creative Biolabs' advanced gene editing platforms enable the design of guide RNAs tailored to FPR1's polymorphic regions, ensuring high specificity for preclinical validation. These innovations position FPR1 as a tractable target for conditions driven by dysregulated immune signaling.
Creative Biolabs offers AAV-mediated FPR1 silencing or overexpression services. Adeno-associated virus (AAV) vectors engineered with tissue-specific promoters facilitate spatially controlled FPR1 modulation. In preclinical models of acute lung injury, intra-tracheal delivery of AAV9-shRNA constructs targeting FPR1 resulted in significant reduction of neutrophil infiltration and alveolar damage. Conversely, AAV-driven FPR1 overexpression in neuronal precursors has demonstrated neuroprotective effects in neurodegenerative models. Creative Biolabs' expertise in viral vector design ensures payload stability and minimal off-target effects, critical for translational success.
Creative Biolabs offers ASO strategies for transcriptional regulation services. ASOs designed to bind FPR1 mRNA can either promote transcript degradation or modulate splicing patterns. For example, splice-switching ASOs have been employed to exclude exons encoding pathogenic FPR1 isoforms in autoimmune disorders. This approach, validated in primary human macrophages, highlights the versatility of ASOs in achieving dose-dependent FPR1 repression. Creative Biolabs' high-throughput screening pipelines accelerate ASO candidate identification, ensuring optimal binding kinetics and bioavailability.
Creative Biolabs offers comprehensive and innovative services to drive the development of FPR1 cell therapy. Please for more services.
Creative Biolabs offers CAR macrophages development services. CAR macrophages engineered to recognize FPR1-overexpressing tumor cells exhibit potent phagocytic activity in solid malignancies. In glioblastoma models, FPR1-directed CAR macrophages infiltrated immunosuppressive microenvironments, significantly reducing tumor burden while sparing healthy tissue. Creative Biolabs' cell engineering platforms optimize receptor affinity and intracellular signaling domains, enhancing both target specificity and cytotoxic efficacy.
Creative Biolabs offers FPR1 antagonist-secreting MSCs development services. Genetically modified MSCs secreting FPR1 antagonists, such as cyclosporin H analogs, have shown promise in dampening neutrophil-driven inflammation in rheumatoid arthritis. Implanted into synovial joints, these cells act as localized “drug factories,” reducing systemic toxicity. Creative Biolabs' expertise in stem cell biomanufacturing ensures scalable production of therapeutic MSCs with consistent potency.
Creative Biolabs offers adoptive T-cell transfer services. T cells engineered with synthetic FPR1-binding receptors selectively eliminate pathogenic cells in autoimmune or fibrotic diseases. Preclinical data in pulmonary fibrosis models revealed that FPR1-targeted T cells reduced collagen deposition by 60% through direct engagement of activated fibroblasts. Creative Biolabs' synthetic biology toolkit streamlines receptor design, enabling rapid iteration of constructs for enhanced safety and efficacy.
The intricate biology of FPR1 demands a multidisciplinary approach, blending cutting-edge gene editing, viral vector design, and cell engineering technologies. Creative Biolabs' 20+ years of experience in antibody and protein research positions us as an ideal partner to de-risk and accelerate your FPR1-targeted drug development.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
