Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Formyl peptide receptor 2 |
| Gene Name | FPR2 |
| Uniprot | P25090 (Human); O88536 (Mouse) |
| Synonym | ALX; ALXR; HM63; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; LXA4R; FMLP-R-II; N-formyl peptide receptor 2; FMLP-R-I; FMLP-related receptor I; LXA4 receptor; RFP; formyl peptide receptor-like 1; lipoxin A4 receptor (formyl peptide receptor related) |
| Background | FPR2, also referred to formyl peptide receptor 2, formyl peptide receptor-like 1 (FPRL1), FMLP-related receptor I (FMLP-R-I), lipoxin A4 receptor (LXA4 receptor, LXA4R), ALX or HM63, is a seven transmembrane G protein-coupled receptor that belongs to the formyl peptide receptor family, involved in antibacterial host defense and inflammatory activity. It is a 38.9 kDa protein of 351 amino acids and encoded by the gene mapping at the chromosome 19q13.41. FPR2 is a low-affinity receptor for N-formyl-methionyl peptides, which are a type of robust neutrophils chemotactic factors. This protein is located on the surface of cell types of many animal species and its associated pathways include the Akt signaling and innate immune system. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX273 | NativeExtract™ Human FPR2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3425K | MemDX™ Membrane Protein Human FPR2 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
M***e: Batch-to-batch consistency ensures reproducible results, streamlining our research on inflammatory signaling pathways.
21/Sep/2023
L**i: Custom modifications, including tagged variants, were delivered rapidly with >95% purity.
16/Mar/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers AAV-mediated FPR2 overexpression services. FPR2's role in resolving inflammation through formyl peptide receptor signaling positions it as a therapeutic candidate for chronic inflammatory pathologies. Adeno-associated virus (AAV) vectors engineered with cell-specific promoters enable spatially restricted FPR2 overexpression in myeloid-derived cells. Preclinical models of colitis demonstrate that AAV-driven FPR2 upregulation reduces leukocyte infiltration and promotes pro-resolving lipid mediator synthesis, thereby accelerating mucosal repair. This platform's modularity allows customization of promoter sequences to target tissue-specific macrophages, ensuring localized therapeutic effects without systemic immune activation.
Creative Biolabs offers FPR2 knock-in services. Gene editing systems tailored for precise genomic integration of FPR2 into microglial progenitors offer a novel strategy to counteract neuroinflammation. In murine Alzheimer's models, knock-in of a constitutively active FPR2 variant enhances phagocytic clearance of Aβ plaques while suppressing pro-inflammatory cytokine release. RNA designs ensure integration fidelity at safe-harbor loci, minimizing off-target risks. Such approaches may synergize with existing immunomodulatory regimens, creating a combinatorial paradigm for neurodegenerative disease management.
Creative Biolabs offers shRNA-based FPR2 silencing services. Tumor-associated macrophages (TAMs) often exploit FPR2 signaling to evade immune surveillance. Lentiviral vectors encoding short hairpin RNA (shRNA) against FPR2 can reprogram TAMs toward an antitumor phenotype. In xenograft models, FPR2 silencing in TAMs enhances cytotoxic T-cell infiltration and reduces immunosuppressive cytokine secretion, leading to tumor regression. Creative Biolabs' proprietary lentiviral packaging systems ensure high-titer, replication-incompetent particles for preclinical validation, accelerating translational pipelines.
Creative Biolabs offers comprehensive and innovative services to drive the development of FPR2 cell therapy. Please for more services.
Creative Biolabs offers CAR macrophages development services. Chimeric antigen receptor (CAR)-macrophages co-expressing FPR2 agonists exhibit enhanced chemotaxis toward tumor hypoxic niches. In glioblastoma models, these engineered cells demonstrate dual functionality: FPR2 activation promotes penetration across the blood-brain barrier, while CAR-directed targeting enables localized tumor phagocytosis. Creative Biolabs' lentiviral transduction protocols achieve >90% CAR expression efficiency in primary macrophages, ensuring robust antitumor activity in heterogeneous malignancies.
Creative Biolabs offers FPR2-edited NK cells development services. Natural killer (NK) cells modified to overexpress FPR2 gain heightened responsiveness to chemotactic cues from infected or malignant tissues. In hepatitis B models, FPR2-enhanced NK cells exhibit superior viral clearance by migrating to hepatocytes harboring covalently closed circular DNA. Gene-editing techniques allow seamless FPR2 incorporation without disrupting endogenous cytotoxicity genes, preserving effector function.
Creative Biolabs offers MSCs secreting FPR2 ligands development services. MSCs engineered to secrete FPR2-specific lipoxin A4 analogs offer a paracrine-driven approach to attenuate autoimmune responses. In rheumatoid arthritis models, these cells localize to inflamed joints, where ligand release induces neutrophil apoptosis and Treg recruitment. Creative Biolabs' MSC differentiation protocols ensure scalable production of clinical-grade cells with consistent immunomodulatory potency.
Therapeutic targeting of FPR2 demands precision in both molecular design and cellular engineering. Creative Biolabs' multidisciplinary expertise—spanning vectorology, genome editing, and cell manufacturing—provides an unparalleled foundation to accelerate your FPR2-focused pipeline. to explore customized solutions tailored to your therapeutic objectives. Let us collaborate to redefine the boundaries of immune-targeted medicine.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
