Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsFrizzled is a family of G protein-coupled receptor proteins that function in multiple signal transduction pathways. It could serve as receptor in one of the three signaling pathways including the canonical Wnt/β-catenin pathway, Wnt/calcium pathway, and planar cell polarity (PCP) pathway. Frizzled proteins have been identified in different animals, from sponges to humans. They play critical roles in the regulation of cell polarity and are essential in governing cell polarity, cell proliferation, formation of neural synapses, embryonic development, and many other processes in developing and adult organisms. Mutations in the human FZD1 receptor are related to familial exudative vitreoretinopathy which is a rare disease affecting the retina of the eye, and the vitreous, the clear fluid inside the eye.
Fig.1 Motifs in Frizzled proteins. (Huang. 2004)
Here shows part of frizzled receptors in humans. Frizzled genes and the proteins they encode have been identified in a range of animals, from sponges to humans. Sequence analysis results suggest that the ten-human frizzled genes can be divided into four main clusters. Frizzled genes from different clusters share 20% to 40% sequence similarity. FZD1, FZD2, and FZD7 share about 75% identity. FZD5 and FZD8 share 70% identity. FZD4, FZD9, and FZD10 share 65% identity. FZD3 and FZD6 share 50% amino acid identity.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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