Introduction of FXYD7
FXYD domain-containing ion transport regulator 7 (FXYD7) is a protein encoded by the human FXYD7 gene. It belongs to the FXYD family which consists of seven single-span transmembrane proteins termed after the invariant extracellular motif Phe-XXX-Tyr-Asp. Studies have shown that FXYD7 could interact with the Na+/K+ ATPase and modulate its kinetic properties.
|Basic Information of FXYD7|
|Protein Name||FXYD domain-containing ion transport regulator 7|
|Organism||Homo sapiens (Human)|
Function of FXYD7 Membrane Protein
FXYD7 belongs to the FXYD family which contains 7 members sharing a signature sequence consisting of the FXYD motif and 3 other conserved amino acid residues. The FXYD protein family has recently been defined as a result of the search for homologues of the Na, K-ATPase gamma subunit, CHIF, and phospholemman in EST and gene data banks. As a member of the FXYD family, FXYD7 undergoes O-glycosylation on three extracellular N-terminal threonine residues, which indicate that it may play a role in protein stability. Studies have shown that FXYD7 is exclusively expressed in brain, both in neurons and glial cells, and may act as a critical role in the regulation of brain function. What’s more, it has been reported that FXYD7 is a novel, tissue- and isoform-specific Na, K-ATPase regulator which could play an important role in neuronal excitability.
Fig.1 Schematic representation of Na+, K+-ATPase structure. (de Lores Arnaiz, 2014)
Application FXYD7 of Membrane Protein in Literature
This article provides new information on structural determinants of general importance for FXYD protein action. It indicates that FXYD7 has a particular regulatory function in the brain.
This article aims to investigate the contribution of amino acids in the transmembrane (TM) domain of FXYD7 to the interaction with Na, K-ATPase. It highlights the important structural and functional role of the TM domain of FXYD7 and delineates the determinants that mediate the complex interactions of FXYD7 with Na, K-ATPase.
This study investigates the biosynthesis, membrane topology, nature, and role of the processing of FXYD7.
This article aims to investigate the tissue distribution and the structural and functional properties of FXYD7. It suggests that FXYD7 is a novel, tissue- and isoform-specific Na, K-ATPase regulator which could play an important role in neuronal excitability.
FXYD7 Preparation Options
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