FXYD7 Membrane Protein Introduction

Introduction of FXYD7

FXYD domain-containing ion transport regulator 7 (FXYD7) is a protein encoded by the human FXYD7 gene. It belongs to the FXYD family which consists of seven single-span transmembrane proteins termed after the invariant extracellular motif Phe-XXX-Tyr-Asp. Studies have shown that FXYD7 could interact with the Na⁺/K⁺ ATPase and modulate its kinetic properties.

Basic Information of FXYD7
Protein Name	FXYD domain-containing ion transport regulator 7
Gene Name	FXYD7
Aliases	N/A
Organism	Homo sapiens (Human)
UniProt ID	P58549
Transmembrane Times	1
Length (aa)	80
Sequence	MATPTQTPTKAPEEPDPFYYDYNTVQTVGMTLATILFLLGILIVISKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV

Function of FXYD7 Membrane Protein

FXYD7 belongs to the FXYD family which contains 7 members sharing a signature sequence consisting of the FXYD motif and 3 other conserved amino acid residues. The FXYD protein family has recently been defined as a result of the search for homologues of the Na, K-ATPase gamma subunit, CHIF, and phospholemman in EST and gene data banks. As a member of the FXYD family, FXYD7 undergoes O-glycosylation on three extracellular N-terminal threonine residues, which indicate that it may play a role in protein stability. Studies have shown that FXYD7 is exclusively expressed in brain, both in neurons and glial cells, and may act as a critical role in the regulation of brain function. What’s more, it has been reported that FXYD7 is a novel, tissue- and isoform-specific Na, K-ATPase regulator which could play an important role in neuronal excitability.

FXYD7 Membrane Protein Introduction Fig.1 Schematic representation of Na+, K+-ATPase structure. (de Lores Arnaiz, 2014)

Application FXYD7 of Membrane Protein in Literature

Crambert G., et al. FXYD7: mapping of functional sites involved in ER export, association with and regulation of Na, K-ATPase. Journal of Biological Chemistry. 2004, 279(29):30888-95. PubMed ID: 15133029

This article provides new information on structural determinants of general importance for FXYD protein action. It indicates that FXYD7 has a particular regulatory function in the brain.
Li C., et al. Role of the transmembrane domain of fxyd7 in functional interactions with Na, K-ATPase. Journal of Biological Chemistry. 2005, 280(52):42738-43. PubMed ID: 16269407

This article aims to investigate the contribution of amino acids in the transmembrane (TM) domain of FXYD7 to the interaction with Na, K-ATPase. It highlights the important structural and functional role of the TM domain of FXYD7 and delineates the determinants that mediate the complex interactions of FXYD7 with Na, K-ATPase.
Crambert G., et al. FXYD7, the first brain-and isoform-specific regulator of Na, K-ATPase. Annals of the New York Academy of Sciences. 2003, 986(1):444-8. PubMed ID: 12763863

This study investigates the biosynthesis, membrane topology, nature, and role of the processing of FXYD7.
Béguin P., et al. FXYD7 is a brain-specific regulator of Na, K-ATPase α1-β isozymes. The EMBO Journal. 2002, 21(13):3264-73. PubMed ID: 12093728

This article aims to investigate the tissue distribution and the structural and functional properties of FXYD7. It suggests that FXYD7 is a novel, tissue- and isoform-specific Na, K-ATPase regulator which could play an important role in neuronal excitability.

FXYD7 Preparation Options

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Reference

de Lores Arnaiz G R and Ordieres M G. (2014). Brain Na+, K+-ATPase activity in aging and disease. International journal of biomedical science. 10(2), 85-102.

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