Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Frizzled class receptor 1 |
| Gene Name | FZD1 |
| Uniprot | Q9UP38 (Human); O70421 (Mouse) |
| Synonym | frizzled-1; Wnt receptor; frizzled 1, seven transmembrane spanning receptor; frizzled family receptor 1; frizzled homolog 1; frizzled, Drosophila, homolog of, 1; fz-1; fzE1; hFz1 |
| Background | FZD1, also known as frizzled class receptor 1, frizzled family receptor 1, frizzled (Drosophila) homolog 1, Fz-1, hFz1 or FzE1, is a transmembrane protein that consists of 647 amino acids and has a molecular mass of about 71 kDa. In humans, it is encoded by the FZD1 gene located on the chromosome 7q21.13. The FZD1 protein contains a signal peptide, seven transmembrane domains, a cysteine-rich domain (CRD) in the N-terminal extracellular region, and a C-terminal PDZ domain-binding motif. It is a member of the G-protein coupled receptor Fz/Smo family and employed as a receptor in the Wnt pathway and other signaling pathways. FZD1 is expressed on the heart, lung, kidney, pancreas, prostate, ovary, placenta in adults, as well as in the fetal lung and kidney. Northern blot analysis displays that its transcript is a 4.5-kb mRNA found in varieties of tissues. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX271 | NativeExtract™ Human FZD1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3639K | MemDX™ Membrane Protein Human FZD1 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MPX0024K | MemDX™ Membrane Protein Human FZD1 Expressed in CHO for Antibody Discovery, Partial (73-253aa) | CHO cell | Partial | N/A |
| Please for more products or customization | ||||
J***an: Batch-to-batch consistency and responsive technical support enable reliable experimental outcomes.
23/Oct/2023
L*o: The custom FZD1 service delivered mammalian-expressed protein within 4 weeks.
09/Jun/2024
FZD1 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
RNA Interference (RNAi)-Mediated FZD1 Silencing
Creative Biolabs offers RNAi-mediated FZD1 silencing services. RNAi-based approaches offer a potent strategy to modulate FZD1 overexpression, a hallmark of Wnt/β-catenin-driven malignancies. Short interfering RNA (siRNA) or short hairpin RNA (shRNA) designed against FZD1 mRNA enables selective degradation, effectively attenuating aberrant Wnt signaling. For instance, lipid nanoparticle-encapsulated FZD1-siRNA has demonstrated efficacy in preclinical models of colorectal cancer, reducing tumor proliferation by >60% through pathway inhibition. Creative Biolabs' proprietary bioinformatics platforms facilitate the design of high-specificity siRNA sequences, minimizing off-target effects while optimizing delivery efficiency.
FZD1 Gene Editing
Creative Biolabs offers FZD1 gene editing services. Gene editing systems enable precise FZD1 knockout or knock-in modifications to correct pathogenic variants or enhance therapeutic responses. In fibrotic disorders, FZD1 disruption has reduced collagen deposition by 45–50% in preclinical lung models by targeting dysregulated Wnt pathways. Creative Biolabs' gene editing validation tools, including single-guide RNA optimization and deep-sequencing-based off-target profiling, ensures translational fidelity for such interventions.
Adeno-Associated Virus (AAV)-Mediated FZD1 Modulation
Creative Biolabs offers AAV-mediated FZD1 modulation services. AAV vectors engineered with tissue-specific promoters enable spatially controlled FZD1 expression or inhibition. For cardiovascular regeneration, AAV9-FZD1-dominant-negative constructs have enhanced cardiomyocyte survival by 30% in ischemic injury models via paracrine Wnt modulation. Creative Biolabs' AAV capsid engineering services allow customization of tropism and transduction efficiency for complex tissues.
Creative Biolabs offers comprehensive and innovative services to drive the development of FZD1 cell therapy. Please for more services.
FZD1-Specific CAR-T Cell Engineering
Creative Biolabs offers FZD1-specific CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells targeting FZD1-positive cells exhibit promise in solid tumors. By incorporating FZD1-specific single-chain variable fragments (scFvs), these engineered T cells achieve 70–80% cytotoxicity in triple-negative breast cancer organoids. Creative Biolabs' CAR construct validation services, including flow cytometry-based activation assays and cytokine release profiling, accelerate preclinical development.
Mesenchymal Stem Cell (MSC)-Based FZD1 Secretion
Creative Biolabs offers MSC-based FZD1 secretion development services. MSCs modified to secrete soluble FZD1 decoy receptors competitively inhibit Wnt ligands, reducing tumor angiogenesis by 40% in glioblastoma models. Creative Biolabs' lentiviral transduction protocols ensure stable transgene expression while maintaining stem cell pluripotency—a critical factor for clinical scalability.
Induced Pluripotent Stem Cell (iPSC)-Derived FZD1-High Progenitors
Creative Biolabs offers iPSC-derived FZD1-high progenitors development services. iPSCs differentiated into FZD1-overexpressing endothelial progenitors enhance vascular repair in diabetic wound models, accelerating healing rates by 2.5-fold. Creative Biolabs' platforms enable controlled FZD1 upregulation without genomic integration risks, ensuring compliance with evolving regulatory standards.
Leverage our end-to-end solutions—from gene editing design to viral vector manufacturing—to de-risk your FZD1-targeted pipeline. for a feasibility assessment or protocol customization.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
