Introduction of FZD3
FZD3 is a 7-transmembrane receptor belonging to the frizzled family. In human, FZD3 is encoded by the FZD3 gene which consists of eight exons and located on chromosome 8p21. It belongs to the G-protein-coupled receptor (GPCR) family which has been studied well during the past few decades as it presents great potential for therapeutic applications. As one of the ten subtypes of the Frizzled family (FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10), it contains seven transmembrane domains with 666 amino acids.
|Basic Information of FZD3|
|Organism||Homo sapiens (Human)|
Function of FZD3 Membrane Protein
The Wnt-signaling pathway has been implicated in a series of processes during the neurodevelopment and frizzled family has been proved to be the receptors for Wnt ligands. It has been reported that Frizzled family plays key roles in cell proliferation, governing cell polarity, formation of neural synapses, embryonic development, and some other processes in developing and adult organisms. Especially, FZD3 is necessary for the formation of the neural crest and major fiber tracts in the CNS. In this case, FZD3 would be associated with the susceptibility to schizophrenia. Diseases associated with FZD3 include Substance-Induced Psychosis and Schizophrenia. Moreover, it has been reported that FZD3 plays an important role in the development of most longitudinal tracts in the central nervous system.
Fig.1 Structure of Frizzled family.
Application of FZD3 Membrane Protein in Literature
OMOD2 is one kind of rare skeletal dysplasia with the characterizations of facial dysmorphism and shortness of the upper extremities. This article reports that heterozygous FZD2mutations may be disease-causing for OMOD2.
This article reveals that the sequential generation of neurons and glial cells is necessary for the wiring and function of the cerebral cortex during development. Celsr3 and FZD3 enable the response of immature neurons Wnt7, and then upregulate Jag1 and thereby accomplish the feedback regulation of apical progenitor fate via Wnt7-Celsr3-Fzd3 signaling.
This article reveals that the deregulation of the planar cell polarity genesCELSR3 and FZD3 might disrupt the enteric innervation pattern and finally result in the susceptibility to HSCR.
This article reveals that Celsr3 and FZD3 enable the formation of the scaffold of pioneer neurons and their axons. This scaffold is able to extend from prethalamus to subcortex and ventral telencephalon and finally steers reciprocal corticothalamic fibers.
This article reports that the assembly of functional neuronal circuits always depends on the correct wiring of axons and dendrites. The seven-transmembrane domain receptors Celsr3 and Fzd3 are able to regulate the development of most longitudinal tracts in the central nervous system, and axon navigation in the peripheral, sympathetic and enteric nervous systems.
FZD3 Preparation Options
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