Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Frizzled class receptor 3 |
| Gene Name | FZD3 |
| Uniprot | Q9NPG1 (Human); Q61086 (Mouse) |
| Synonym | Fz-3; frizzled-3; frizzled 3, seven transmembrane spanning receptor; frizzled family receptor 3; frizzled homolog 3 |
| Background | FZD3 is a 7-transmembrane receptor belonging to the frizzled family. In human, FZD3 is encoded by the FZD3 gene which consists of eight exons and located on chromosome 8p21. It belongs to the G-protein-coupled receptor (GPCR) family which has been studied well during the past few decades as it presents great potential for therapeutic applications. As one of the ten subtypes of the Frizzled family (FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10), it contains seven transmembrane domains with 666 amino acids. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX269 | NativeExtract™ Human FZD3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3649K | MemDX™ Membrane Protein Human FZD3 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
R***y: Ideal for high-throughput screening platforms requiring low aggregation.
14/Oct/2023
FZD3 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
FZD3 Allelic Correction
Creative Biolabs offers FZD3 allelic correction services. Genome editing enables precise correction of FZD3 genetic variants linked to neurodevelopmental disorders. For example, single-nucleotide polymorphisms (SNPs) in FZD3, such as rs2241802 and rs2323019, have been associated with altered Wnt/β-catenin signaling pathways in schizophrenia. By designing sgRNAs complementary to these loci, genome editing systems can excise disease-associated alleles and insert functional sequences, restoring normal receptor activity. Creative Biolabs' genotyping services provide critical support for identifying targetable FZD3 variants in patient cohorts, ensuring the development of personalized gene therapy.
AAV-Delivered FZD3 shRNA for Oncological Applications
Creative Biolabs offers AAV-delivered FZD3 shRNA development services. Adeno-associated virus (AAV) vectors engineered with short hairpin RNA (shRNA) against FZD3 mRNA offer a promising strategy to inhibit Wnt-driven tumorigenesis. In cancers where FZD3 overexpression activates oncogenic β-catenin signaling, AAV-shRNA constructs can silence FZD3 transcription, reducing metastasis and cell proliferation. Preclinical models demonstrate that this approach achieves >70% knockdown efficiency in xenografts. Creative Biolabs' viral vector development platform optimizes tropism and payload delivery for cell-specific targeting, enhancing therapeutic precision.
Creative Biolabs offers comprehensive and innovative services to drive the development of FZD3 cell therapy. Please for more services.
FZD3-Modified Neural Stem Cell Implant
Creative Biolabs offers FZD3-modified neural stem cell implant development services. Neural stem cells (NSCs) engineered to overexpress FZD3 receptors exhibit enhanced differentiation into dopaminergic neurons, as evidenced by preclinical studies in Parkinsonian models. By activating Wnt signaling, FZD3-modified NSCs integrate into damaged neural circuits, promoting functional recovery. Creative Biolabs' immunofluorescence imaging services enable real-time tracking of FZD3 expression and localization in transplanted cells, ensuring quality control during therapy development.
CAR-T Cells Targeting FZD3+ Solid Tumors
Creative Biolabs offers CAR-T cells targeting FZD3+ solid tumors development services. Chimeric antigen receptor (CAR)-T cells redirected against FZD3 surface epitopes show efficacy in treating Wnt-dependent malignancies. For instance, CAR-T constructs targeting FZD3-positive glioblastoma cells induce tumor regression in murine models through cytotoxic granzyme release. Creative Biolabs' cell-specific viral vectors, including AAV serotypes optimized for T-cell transduction, accelerate the production of these advanced therapeutics.
Our integrated solutions—from genotyping to viral vector design—empower researchers to advance FZD3-targeted interventions. to explore custom strategies for your gene or cell therapy pipeline.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
