Introduction of FZD6
FZD6 is encoded by the FZD6 gene. It belongs to the G-protein-coupled receptor (GPCR) family which shows numerous possibilities for therapeutic applications in recent decades. FZD6 is one of the ten subtypes of the Frizzled family (FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10) with 706 amino acids. Different from other family members, FZD6 does not contain the C-terminal PDZ domain-binding motif.
|Basic Information of FZD6|
|Aliases||FZ6, FZ-6, HFZ6, NDNC10|
|Organism||Homo sapiens (Human)|
Function of FZD6 Membrane Protein
FZD6 belongs to the Frizzled family whose members have been served as receptors for Wnt signaling proteins. In general, the frizzled receptors can be coupled to the β-catenin canonical signaling pathway and finally leads to various applications, such as inhibition of GSK-3 kinase, activation of Wnt target genes, activation of disheveled proteins, and nuclear accumulation of β-catenin. The FZD6 is over-expressed in the keratogenous zone of the ventral matrix. FZD6 has been shown to act as the positive regulator for the noncanonical WNT or planar cell polarity pathway and the negative regulator for the canonical WNT/β-catenin signaling cascade. The diseases related to FZD6 include nail disorder and nail disease. It has been reported that FZD6 mutation has been identified in isolated nail dysplasia.
Fig.1 Structure of FZD6.
Application of FZD6 Membrane Protein in Literature
Liver tumor-initiating cells (TICs) are the drivers for liver tumorigenesis. This article reports that IncFZD6 enables the promotion of Wnt/β-catenin activation and self-renewal of liver TIC via BRG1-dependent FZD6 expression.
This article reports that FZD6 is frequently amplified in breast cancer and increase the incidence of the triple negative breast cancer subtype. The FZD6-fibronectin-actin axis might be used for the drug development of breast cancer.
This article reveals that the FZD6-regulated Wnt non-canonical pathway plays an important role in the pathogenesis of various human malignancies. The research of FZD6 might result in the identification of new targets for cancer treatment.
This article reveals that the research of FZD6 might be the first step for the diagnostic of autosomal recessive NDNC patients with enlarged nails.
This article reports that FZD6 works as the negative regulator of TCF4-miR-125b/miR-20b-FZD6 via the activation of CaMKII-TAK1-NLK signaling. The components of this circuit relate to the prognostic of clinical glioblastoma (GBM). This article provides insights into GBM pathogenesis understanding and treatment.
FZD6 Preparation Options
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