Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Frizzled class receptor 6 |
| Gene Name | FZD6 |
| Uniprot | O60353 (Human); Q61089 (Mouse) |
| Synonym | FZ6; FZ-6; HFZ6; NDNC1; NDNC10; frizzled-6; frizzled 6, seven transmembrane spanning receptor; frizzled family receptor 6; frizzled homolog 6; seven transmembrane helix receptor |
| Background | The Frizzled-6 (FZD6) receptor, directly encoded by the FZD6 gene, is recognized as an integral component of the expansive G-protein-coupled receptor (GPCR) superfamily. This family, owing to its remarkable versatility and involvement in diverse physiological processes, has garnered considerable attention in recent decades for its substantial potential in developing novel therapeutic modalities. FZD6 itself represents one of the ten identified subtypes within the broader Frizzled family (FZD1-FZD10). This particular isoform comprises a polypeptide chain of 706 amino acids. What notably differentiates FZD6 from its paralogs, however, is the conspicuous absence of a C-terminal PDZ domain-binding motif, a structural feature that is commonly observed in other family members. This unique characteristic perhaps hints at distinct intracellular signaling partnerships or regulatory mechanisms, warranting further rigorous investigation into its specific biological functions and therapeutic utility. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX267 | NativeExtract™ Human FZD6 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3653K | MemDX™ Membrane Protein Human FZD6 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
Ca***an: Its consistency in receptor-ligand binding studies significantly reduced experimental variability, essential for our signaling research.
16/Jul/2023
L***an: The customized FZD6 protein met stringent specifications (mutations, tags) with rapid delivery.
22/Feb/2024
FZD6 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
FZD6 Pathway Modulation
Creative Biolabs offers FZD6 pathway modulation services. Targeted disruption of FZD6 signaling cascades can be achieved via gene editing, enabling precise correction of oncogenic Wnt pathway mutations or epigenetic silencing of aberrant FZD6 overexpression. Creative Biolabs' proprietary RNA design platforms optimize specificity, minimizing off-target effects while ensuring robust cleavage efficiency in diverse cellular models. For instance, in triple-negative breast cancer (TNBC), gene-edited FZD6 knockdown has demonstrated significant suppression of metastatic phenotypes in vivo.
AAV9-Directed FZD6 Transcriptional Activation
Creative Biolabs offers AAV9-directed FZD6 transcriptional activation services. Recombinant adeno-associated virus (AAV9) vectors engineered with tissue-specific promoters facilitate selective FZD6 expression in regenerative contexts, such as bone fracture repair. Creative Biolabs' AAV serotype screening pipelines enhance tropism for osteoprogenitor cells, achieving >70% transduction efficacy in preclinical models. This approach synergizes with pharmacodynamic modeling to refine dosing intervals, ensuring sustained therapeutic protein levels.
shRNA-Based FZD6 Silencing via Lipid Nanoparticles
Creative Biolabs offers siRNA-based FZD6 silencing services. Lipid-encapsulated short hairpin RNAs (shRNAs) targeting FZD6 mRNA offer a transient yet potent strategy for modulating Wnt signaling in fibrotic disorders. Creative Biolabs' biocompatible lipid formulations improve hepatic uptake in cirrhotic models, reducing collagen deposition by 50% post-treatment.
Creative Biolabs offers comprehensive and innovative services to drive the development of FZD6 cell therapy. Please for more services.
CAR-T Cells Engineered for FZD6+ Solid Tumors
Creative Biolabs offers CAR-T cells engineered for FZD6+ solid tumors development services. Chimeric antigen receptor (CAR)-T cells targeting FZD6 extracellular domains exhibit potent cytotoxicity against FZD6-overexpressing malignancies, including ovarian and pancreatic carcinomas. Creative Biolabs' RNA sequencing platforms validate target engagement, while cytokine release profiling ensures safety in immunocompetent models.
iPSC-Derived Neurons with FZD6 Knockout
Creative Biolabs offers iPSC-derived neurons development services with FZD6 knockout. Induced pluripotent stem cells (iPSCs) edited to lack FZD6 expression differentiate into dopaminergic neurons with enhanced viability in Parkinson's disease models. Creative Biolabs' neural differentiation protocols achieve 90% purity, coupled with high-content imaging to map FZD6's role in synaptic connectivity.
Mesenchymal Stem Cells (MSCs) Secreting FZD6 Antagonists
Creative Biolabs offers MSCs secreting FZD6 antagonists development services. MSCs engineered to secrete FZD6-neutralizing antibodies localize to tumor microenvironments, inhibiting Wnt-driven angiogenesis. Creative Biolabs' 3D bioprinting technologies enable scalable production of hypoimmunogenic MSCs, with in vivo tracking confirming >28-day engraftment.
Leverage Creative Biolabs' cutting-edge cellular engineering platforms to pioneer FZD6-targeted therapies. for bespoke protocol design and preclinical validation.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
