Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Frizzled class receptor 7 |
| Gene Name | FZD7 |
| Uniprot | O75084 (Human); Q61090 (Mouse) |
| Synonym | FzE3; frizzled-7; Frizzled, drosophila, homolog of, 7; frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; fz-7; hFz7 |
| Background | Frizzled is a family of G protein-coupled receptor proteins, which serves as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Disheveled in the cytosol. Frizzled proteins and the genes encoding them have been identified in a series of animals from sponges to humans. Frizzled-7 (FZD7) is a protein that in humans encoded by the FZD7 gene. Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, seven putative transmembrane domains, ten cysteine residues typical of the cysteine-rich extracellular domain of 10 typical Fz family members, and an intracellular C-terminal tail with a PDZ domain-binding motif. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX386 | NativeExtract™ Human FZD7 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3626K | MemDX™ Membrane Protein Human FZD7 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MP0387X | MemDX™ Membrane Protein Human FZD7 (Frizzled class receptor 7) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| S01YF-0423-KX650 | MemDX™ Membrane Protein Human FZD7 (33-254aa) Expressed in HEK293, N-Human Fc tag | HEK293 cell | Partial | N/A |
| MPX0028K | MemDX™ Membrane Protein Human FZD7 (Frizzled class receptor 7) Expressed in CHO for Antibody Discovery, Partial (33-185aa) | CHO cell | Partial | N/A |
| Please for more products or customization | ||||
Ot***ie: Consistently obtained high-pure FZD7 in lyophilized form with intact functional activity.
05/Nov/2023
S***n: Received tailored extracellular domain batches within 3 weeks.
15/Jun/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Structural Insights-Driven AAV Vector Design for FZD7 Antagonist Delivery
Creative Biolabs offers structural insights-driven AAV vector design services. The development of adeno-associated virus (AAV) vectors engineered to deliver FZD7-targeted antagonists represents a transformative approach in gene therapy. Leveraging high-resolution structural data from FZD7 receptor studies, these vectors enable precise delivery of therapeutic agents such as peptide antagonists, which selectively bind to the cysteine-rich domain (CRD) of FZD7, disrupting Wnt/β-catenin signaling. Preclinical models demonstrate that AAV-mediated expression of Fz7-21 reduces tumor stemness and metastasis in Wnt-driven cancers. Creative Biolabs’ expertise in viral vector optimization ensures enhanced transduction efficiency and tissue specificity, critical for therapeutic success.
FZD7 Knockout for Tumor Suppression
Creative Biolabs offers FZD7 knockout services. Gene editing technology offers a robust platform for directly targeting FZD7 genomic loci in cancer cells. By ablating FZD7 expression, this strategy effectively inhibits canonical Wnt signaling, thereby suppressing tumor progression and chemoresistance. Recent studies highlight its utility in triple-negative breast cancer models, where FZD7 knockout reduced metastatic potential by >60%. Creative Biolabs’ validated libraries and genotyping services provide end-to-end support for such therapeutic pipelines.
Creative Biolabs offers comprehensive and innovative services to drive the development of FZD7 cell therapy. Please for more services.
CAR-T Cell Engineering with FZD7-Specific Chimeric Antigens
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells engineered to recognize FZD7-overexpressing tumors represent a paradigm shift in cell therapy. Utilizing structural insights from FZD7-G protein complexes, these CAR-T cells target epitopes critical for Wnt ligand binding, triggering selective tumor cell lysis. Early-phase trials in hepatocellular carcinoma show promising tumor regression rates. Creative Biolabs’ immunofluorescence platforms facilitate real-time validation of CAR-T cell targeting specificity, ensuring therapeutic precision.
FZD7-Silenced Mesenchymal Stem Cells for Tumor Microenvironment Modulation
Creative Biolabs offers FZD7-silenced mesenchymal stem cells development services for tumor microenvironment modulation. Mesenchymal stem cells (MSCs) genetically modified to silence FZD7 expression via shRNA payloads disrupt Wnt-mediated tumor-stroma crosstalk. These cells secrete anti-angiogenic factors and inhibit metastatic niche formation in colorectal cancer models, achieving >50% reduction in tumor volume. Creative Biolabs’ gene expression profiling services enable rigorous monitoring of FZD7 knockdown efficacy across diverse cell states.
From viral vector design to CAR-T cell validation, Creative Biolabs delivers end-to-end solutions for FZD7-focused drug development. Our advanced genotyping, gene expression analysis, and viral vector optimization services are tailored to accelerate your preclinical pipelines. to explore custom strategies for your FZD7-targeted therapies.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
