Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsThe class C G-protein-coupled receptors are a class of G-protein coupled receptors. Similar to other GPCRs, the molecular structure of family C GPCRs contains an N-terminal signal sequence, 7TM domains that are linked by three intracellular, three extracellular loops, and an intracellular C-terminal amino acid sequence.
The ECD of family C GPCRs has been found to be closely related to bacterial periplasmic amino acid binding proteins, which transport nutrients from the extracellular to the intracellular space in bacteria. On the other hand, the 7TM domain of family C GPCRs is phylogenetically related to rhodopsin-like (family A) GPCRs. Family C G-protein-coupled receptors are characterized by a large extracellular domain containing the orthosteric agonist binding site known as the "Venus Flytrap Module" because of the dynamics of their bifida structures and their activation mechanism. Many suitable biochemical and electrophysiological assay systems reveal the complexity of the interaction between orthosteric and allosteric ligands. Many allosteric class C GPCR modulators show in vivo efficacy in a variety of behavioral models of clinical indications.
Fig.1 Schematic representation of a family C GPCR protein. (Urwyler, 2011)
The class C G-protein-coupled receptors comprise various pheromone, vomeronasal, and taste receptors, the calcium-sensing receptor (CaSR), as well as gamma-amino-butyric acid (GABA) type B receptors and glutamate receptors. Here shows part of family C G-protein-coupled receptors in humans:
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell lines.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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