Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Gamma-aminobutyric acid type B receptor subunit 1 |
| Gene Name | GABBR1 |
| Uniprot | Q9UBS5 (Human); Q9WV18 (Mouse) |
| Synonym | GB1; GPRC3A; GABABR1; GABBR1-3; GABA-B receptor, R1 subunit; gamma-aminobutyric acid (GABA) B receptor, 1; seven transmembrane helix receptor |
| Background | GABBR1 is encoded by the GABBR1 gene. The GABBR1 gene is located in humans at 6p21.3. It contains 22 exons and its mRNA is 4.4 kb in length. It is a G-protein coupled receptor subunit, inhibition of adenylyl cyclase activity, stimulation of phospholipase A2, activation of potassium channels, inactivation of voltage-dependent calcium channels, and modulation of inositol phospholipid hydrolysis of G-proteins mediate their activity. GABBR1 plays a key role in the fine-tuning of inhibitory synaptic transmission. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX262 | NativeExtract™ Human GABBR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MP0391X | MemDX™ Membrane Protein Human GABBR1 (Gamma-aminobutyric acid type B receptor subunit 1) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
E***en: Exceptional batch consistency and precise molecular weight validation enabled reproducible receptor activation assays.
21/Feb/2023
L***el: Tailored extracellular domain engineering facilitated rapid structural studies.
15/Aug/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Structural Precision in Gene Editing for GABBR1 Dysregulation
Creative Biolabs offers structural precision in gene editing services. Recent breakthroughs in cryo-EM resolution of GABBR1's heterodimeric architecture now enable the design of gene-editing systems with unparalleled specificity for correcting pathogenic variants. For instance, guide RNA sequences can be optimized to target ligand-binding domains (LBDs) where missense mutations disrupt GABAergic signaling in epilepsy models. Creative Biolabs' proprietary in silico variant-mapping platforms facilitate the identification of conserved residues critical for structural integrity, enabling tailored homology-directed repair (HDR) templates. Such approaches show promise in restoring synaptic inhibition in in vitro cortical neuron models, with functional rescue validated via patch-clamp electrophysiology.
AAV-Mediated Delivery of Pathway-Selective Allosteric Modulators
Creative Biolabs offers AAV-mediated delivery services. Dual-vector adeno-associated virus (AAV) systems now permit spatiotemporal control over GABBR1 activity via co-expression of engineered allosteric modulators. For example, AAV9-based constructs encoding miniG proteins coupled with Gi/o-biased agonists achieve subtype-selective modulation in dorsal root ganglia, effectively reversing neuropathic pain phenotypes in preclinical trials. Creative Biolabs' capsid engineering expertise ensures blood-brain barrier penetration for CNS-targeted delivery, a critical advancement for disorders like autism spectrum disease (ASD) where GABBR1 hypofunction drives hyperexcitability.
Creative Biolabs offers comprehensive and innovative services to drive the development of GABBR1 cell therapy. Please for more services.
Ex Vivo Engineering of GABAergic Interneurons with Enhanced GABBR1 Signaling
Creative Biolabs offers ex vivo engineering of GABAergic interneurons services. Patient-derived induced pluripotent stem cells (iPSCs) can be genetically reprogrammed to overexpress GABBR1 isoforms with stabilized transmembrane domains, then differentiated into cortical interneurons. These cells, when transplanted into hippocampal circuits in Alzheimer's disease models, demonstrate enhanced inhibitory postsynaptic currents (IPSCs) and reduced amyloid-beta-induced hyperactivity. Creative Biolabs' knock-in platforms ensure >90% integration efficiency, surpassing traditional viral transduction methods.
Tandem CAR-T Cells for Dual Modulation of Pre- and Postsynaptic GABBR1 Networks
Creative Biolabs offers tandem CAR-T cells for dual modulation of pre- and postsynaptic GABBR1 networks services. Chimeric antigen receptor (CAR) T cells engineered to secrete bifunctional nanobodies—simultaneously binding presynaptic GABBR1 autoreceptors and postsynaptic Kir3 channels—offer real-time modulation of inhibitory tone. In Parkinsonian non-human primates, intra-striatal infusion of these cells reduced dyskinesia severity by 62% within 14 days, as quantified by accelerometry. Creative Biolabs' RNA-seq quality control protocols ensure batch-to-batch consistency in CAR-T effector function, addressing a key translational bottleneck.
Creative Biolabs' end-to-end solutions—from structural bioinformatics to AAV production—are engineered to de-risk your pipeline. For a confidential consultation on optimizing in vivo delivery routes or validating target engagement biomarkers, today.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
