Introduction of GABRA2
Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2), also known as GABA(A) receptor subunit alpha-2, is encoded by the GABRA2 gene in humans. It belongs to the big GABAA receptors family which is heteropentameric, ligand-gated anion channels activated by GABA to mediate both phasic synaptic transmission and tonic extrasynaptic inhibition in the brain.
|Basic Information of GABRA2|
|Protein Name||Gamma-aminobutyric acid receptor subunit alpha-2|
|Aliases||GABA(A) receptor subunit alpha-2|
|Organism||Homo sapiens (Human)|
Function of GABRA2 Membrane Protein
GABA is the primary inhibitory neurotransmitter in the central nervous system and exerts its effects through binding at ionotropic (GABAA) and metabotropic (GABAB) receptors. GABRA2 is a member of GABAA receptors which are heteropentameric, ligand-gated anion channels activated by GABA to mediate both phasic synaptic transmission and tonic extrasynaptic inhibition in the brain. Studies have shown that GABRA2 is mainly expressed in brain reward circuitry including the amygdala, the ventral tegmental area, and the nucleus accumbens. It has been reported that GABRA2 potentially plays a role in the etiology of problematic drinking. What’s more, associations have been reported between GABRA2 variants and a number of alcohol-related phenotypes across developmental periods, such as adult alcohol dependence, subclinical alcohol-related risk behaviors in late adolescence and young adulthood, and problem behaviors predictive of alcohol misuse-such as conduct problems and rule-breaking behavior-during early to mid-adolescence.
Fig.1 Structure of the GABAA receptor.
Application GABRA2 of Membrane Protein in Literature
This article suggests that a de novo mutation in GABRA2 is likely to cause autosomal dominant EOEE accompanied by a movement disorder and vision impairment.
This article aims to investigate the effects of GABRA2 genotype and stressful life events on aggressive behavior, alcohol use frequency and occurrence of alcohol use disorder. It suggests that the GABRA2 genotype interacts with stress in young people with an impact on the development of alcohol use and aggressive behavior.
This study demonstrates that GABRA2 (rs279858) genotype has an indirect effect on drinking through subjective response. Furthermore, it also indicates that the influence of SR on developing dependence differs based on rs279858 genotype.
This report finds that there exist three externalizing trajectory classes (i.e., low, decreasing, and high) across adolescence. Furthermore, a GABRA2 × Parental Monitoring effect on class membership is observed, such that A-carriers are largely unaffected by parental monitoring, whereas class membership for those with the GG genotype is affected by parental monitoring.
This article aims to examine the allelic and haplotypic association of the GABRA2 gene with alcohol dependence and related aggressive behavior in subjects of Eastern European (Croatian) origin. It indicates that the GABRA2 gene is associated with alcohol dependence-related aggressive behavior.
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