Introduction of GABRA3
Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3), also known as GABA-A receptor subunit alpha 3, is a protein that in humans is encoded by the GABRA3 gene. It is a subunit of the gamma-aminobutyric acid (GABA) type A receptor family of heteromeric pentameric ligand-gated ion channels.
|Basic Information of GABRA3|
|Protein Name||Gamma-aminobutyric acid receptor subunit alpha-3|
|Aliases||GABA(A) receptor subunit alpha-3|
|Organism||Homo sapiens (Human)|
Function of GABRA3 Membrane Protein
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the mammalian brain that specifically interacts with two major classes of receptors: GABA-A receptor (α1–6, β1–3, γ1–3, δ, ε, θ, π, ρ1–3) and GABA-B receptor (GABBR1 and GABBR2). As a member of the GABA-A receptor family, GABARA3 is expressed much more strongly in normal human tissues than in other adult organs with the highest GABARA3 expression being in the fetal brain. The GABARA3 expression is also pronounced in the cortex and thalamus at embryonic and early postnatal stages in rat, indicating its role in the development of cortical plate. What’s more, studies have shown that high expression of GABRA3 is associated with disease stage, lymphatic metastasis status and poor patient survival, which including but not limited to lung adenocarcinoma and breast cancer.
Fig.1 Modulation of extrasynaptic GABAA receptors. (Connelly, 2013)
Application GABRA3 of Membrane Protein in Literature
This article suggests that miR-92b-3p may act as a tumor suppressor by targeting Gabra3-associated oncogenic pathways which provide novel insight into future treatments for pancreatic cancer patients.
This article reports that the expressions of Gabra3 and Lpl are significantly correlated with the severity of liver injury (p<0.05) demonstrating that these genes may be linked to the susceptibility to APAP-induced hepatotoxicity.
This article suggests that high GABRA3 protein expression in lung adenocarcinoma is correlated with disease stage, lymphatic metastasis status and poor patient survival which indicates that GABRA3 could promote lymph node metastasis and thus be an effective therapeutic target for anticancer treatment.
This article suggests that Gabra3 could activate the AKT pathway to promote breast cancer cell migration, invasion, and metastasis. It demonstrates that mRNA-edited Gabra3 plays a significant role in breast cancer metastasis.
This article suggests that GABRA3 has the ability to regulate a behavioral endophenotype of depression and it can be used as a viable new target for the study and treatment of human depression.
GABRA3 Preparation Options
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