Introduction of GABRD
Gamma-aminobutyric acid receptor subunit delta (GABRD), also known as GABA(A) receptor subunit delta, is a protein that in humans is encoded by the GABRD gene. It is a member of the GABAA receptors (GABAARs), which are composed of different subunits arranged in pentameric assemblies, with specific subunit compositions determining their regional distribution, kinetics, and pharmacology.
|Basic Information of GABRD|
|Protein Name||Gamma-aminobutyric acid receptor subunit delta|
|Aliases||GABA(B) receptor subunit delta|
|Organism||Homo sapiens (Human)|
Function of GABRD Membrane Protein
GABAA receptors containing δ subunits (δ-GABAARs) are GABA-gated ion channels with extra- and perisynaptic localization, strong sensitivity to neurosteroids (NS), and a high degree of plasticity. As a member of the GABAA receptors, GABRD is a high affinity, low efficacy non-synaptic GABAA receptor with a high sensitivity to neurosteroids. Recently, GABRD receptor has attracted considerable attention as it could significantly reduce neuronal excitability in vitro and also regulate neurogenesis, memory, nociception, maternal behaviors, and responses to stress. It also functions to dampen network excitability and prevent excessive excitation. What’s more, studies have shown that dysregulation of GABRD receptor expression may be involved with several disorders, including neurodegenerative diseases, stroke, depression, epilepsy, schizophrenia, and traumatic brain injury.
Fig.1 The Structure of GABAA Receptor Subunit. (Charych, 2009)
Application GABRD of Membrane Protein in Literature
This article aims to study the expression of gamma-aminobutyric acid type A receptor delta subunit (GABRD) in human and rodent sperm and its involvement in mediating the progesterone-induced acrosome reaction. It suggests that GABRD represents a novel progesterone receptor or modulator in spermatozoa that is responsible for the progesterone-induced Ca2+ influx required for the acrosome reaction through its interaction with the P2X2 receptor.
This article indicates that δGABAARs are involved in the modulating of the respiratory network, which is critical to understand how δGABAARs change breathing in pathological conditions affecting extra-synaptic GABAA receptor function such as exposure to anesthetics and neurosteroids.
This article suggests that δGABAA receptors are necessary for synaptic plasticity in the CA3 subfield. Drugs that enhance δGABAA receptor function may reverse deficits in synaptic plasticity in the CA3 subfield and improve pattern separation in neurological disorders.
This article suggests that δ-GABAAR plays an important role in estrous cycle-mediated fluctuations in hippocampus-dependent learning and memory.
This article shows the importance of the GABAAR δ subunit in the regulation of CRH neurons, and thus the HPA axis, and demonstrate that dysregulation of CRH neurons alters stress-related behaviors.
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