Introduction of GABRR1
The Gamma-aminobutyric acid receptor subunit rho-1(GABRR1), which in humans is encoded by the GABRR1 gene, is also known as a GABA-ρ receptor. GABA is the major inhibitory neurotransmitter in the vertebrate brain, mediating neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. GABA(A) receptor subunit rho-1 can play an important role in retinal neurotransmission.
|Basic Information of GABRR1|
|Protein Name||Gamma-aminobutyric acid receptor subunit rho-1|
|Aliases||GABA(A) receptor subunit rho-1, GABA(C) receptor|
|Organism||Homo sapiens (Human)|
Function of GABRR1 Membrane Protein
GABA is the major inhibitory neurotransmitter throughout most of the mature nervous system. Three types of GABA receptors are reported: GABAA, GABAB, and GABAC (GABRR1) receptors. The GABRR1, a postsynaptic membrane receptor expressed prominently in the retina, is a ligand-gated ion channel that consists of a combination of ρ subunits. GABRR1 belongs to the Cys-loop superfamily of ligand-gated ion channels. GABRR1 are expressed mainly in the retina, although they have been identified in a variety of central nervous systems. GABRR1 are pentameric, sharing common structural characteristics with other Cys-loop receptor members. Three isoforms of GABAC-ρ subunits (ρ1, ρ2 and ρ3) have been identified in human. The ρ subunits can form homopentameric GABRR1. The GABRR1, a sub-family of GABAA, consist of ρ subunits and are expressed in brain tissue, with especially high expression in retina. The availability of an antibody to the human GABAC ρ1 subunit would facilitate research on ρ1-containing GABAC receptors, and potentially also clinical studies aimed at selectively targeting tissues rich in ρ1.
Fig.1 The structure of GABA receptor.
Application of GABRR1 Membrane Protein in Literature
The article suggests a novel role for GABAC receptors in modulating slow synaptic transmission, as indicated by changes in [Ca2+]i transients, within the ENS.
The article suggests that changes in GABAergic function could be an important factor in both early and later stages of AD pathogenesis.
The article reveals that the increased GABA shunt could be the supply of intermediates to feed the tricarboxylic acid cycle of respiration metabolism during a long-term heat stress, thereby maintaining metabolic homeostasis.
This review considers the role of GABA in the circadian pacemaker, in the mechanisms responsible for the generation of circadian rhythms, in the ability of non-photic stimuli to reset the phase of the pacemaker, and in the ability of the day-night cycle to entrain the pacemaker.
The authors define a nuanced mechanism whereby the GABAA-R uses the general zwitterionic features of the GABA molecule to identify a potential ligand some 2 nm away from the binding site.
GABRR1 Preparation Options
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