Introduction of GABRR3
The Gamma-aminobutyric acid receptor subunit rho-3(GABRR3), which in humans is encoded by the GABRR3 gene, is also known as a GABAA-ρ receptor. GABRR3 is a member of the rho subunit family, which is also named as GABA(C) receptor. GABA receptors are ligand-gated chloride channels. GABA is a major inhibitory neurotransmitter in the mammalian brain. GABRR3 may play an important role in retinal neurotransmission.
|Basic Information of GABRR3|
|Protein Name||Gamma-aminobutyric acid receptor subunit rho-3|
|Aliases||GABA(A) receptor subunit rho-3, GABA(C) receptor|
|Organism||Homo sapiens (Human)|
Function of GABRR3 Membrane Protein
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain. GABAergic receptor abnormalities have been found playing an important role in several major psychiatric disorders, including schizophrenia, mood disorders, and autism. The γ-aminobutyric acid type C (GABAC) receptors, also known as γ-aminobutyric acid type A rho (GABAA-ρ) receptors are ligand-gated ion channel receptors that activated by GABA, the most inhibitory neurotransmitter substance in the vertebrate CNS (central nervous system). GABAC Receptors are consist of three subunits (ρ1-3) that originally belonged to the GABAA Receptor subtype has been associated to memory, learning, visual processing, regulation of sleep–waking rhythms, pain perception, regulation of hormones and neuroendocrine gastrointestinal secretion. These receptors are localized in the retina, thalamus, hippocampus, pituitary and gastro intestinal tract.
Fig.1 The structure of GABAC receptors. (Strauss, 2011)
Application of GABRR3 Membrane Protein in Literature
This article provides new information supporting the role of missense GABA-A receptor polymorphisms in reaction time, motor time and effects of low ethanol doses in vivo.
The article suggests that changes in GABAergic function could be an important factor in both early and later stages of AD pathogenesis.
The article reveals that the increased GABA shunt could be the supply of intermediates to feed the tricarboxylic acid cycle of respiration metabolism during long-term heat stress, thereby maintaining metabolic homeostasis.
The research suggests that GABRR3rs832032 polymorphism is associated with the risk for RLS, and there is a modifier effect of GABRA4 rs2229940 on the age of onset of RLS.
The results suggest that GABRR genes seem to be not associated with the risk of migraine in Caucasian Spanish people.
GABRR3 Preparation Options
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