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GABRR3 Membrane Protein Introduction

Introduction of GABRR3

The Gamma-aminobutyric acid receptor subunit rho-3(GABRR3), which in humans is encoded by the GABRR3 gene, is also known as a GABAA-ρ receptor. GABRR3 is a member of the rho subunit family, which is also named as GABA(C) receptor. GABA receptors are ligand-gated chloride channels. GABA is a major inhibitory neurotransmitter in the mammalian brain. GABRR3 may play an important role in retinal neurotransmission.

Basic Information of GABRR3
Protein Name Gamma-aminobutyric acid receptor subunit rho-3
Gene Name GABRR3
Aliases GABA(A) receptor subunit rho-3, GABA(C) receptor
Organism Homo sapiens (Human)
UniProt ID A8MPY1
Transmembrane Times 4
Length (aa) 467
Sequence MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQKYEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV

Function of GABRR3 Membrane Protein

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain. GABAergic receptor abnormalities have been found playing an important role in several major psychiatric disorders, including schizophrenia, mood disorders, and autism. The γ-aminobutyric acid type C (GABAC) receptors, also known as γ-aminobutyric acid type A rho (GABAA-ρ) receptors are ligand-gated ion channel receptors that activated by GABA, the most inhibitory neurotransmitter substance in the vertebrate CNS (central nervous system). GABAC Receptors are consist of three subunits (ρ1-3) that originally belonged to the GABAA Receptor subtype has been associated to memory, learning, visual processing, regulation of sleep–waking rhythms, pain perception, regulation of hormones and neuroendocrine gastrointestinal secretion. These receptors are localized in the retina, thalamus, hippocampus, pituitary and gastro intestinal tract.

The structure of GABAC receptors. Fig.1 The structure of GABAC receptors. (Strauss, 2011)

Application of GABRR3 Membrane Protein in Literature

  1. García-Martín E., et al. Missense Gamma-Aminobutyric Acid Receptor Polymorphisms Are Associated with Reaction Time, Motor Time, and Ethanol Effects in Vivo. Frontiers in Cellular Neuroscience. 2018,12: 10. PubMed ID: 29445327

    This article provides new information supporting the role of missense GABA-A receptor polymorphisms in reaction time, motor time and effects of low ethanol doses in vivo.

  2. Lee V. and Jamie M. The Impact of Tonic GABAA Receptor-Mediated Inhibition on Neuronal Excitability Varies across Brain Region and Cell Type. Frontiers in Neural Circuits. 2014, 8: 3. PubMed ID: 24550784

    The article suggests that changes in GABAergic function could be an important factor in both early and later stages of AD pathogenesis.

  3. Li Z., et al. Metabolic Pathways Regulated by Γ-Aminobutyric Acid (GABA) Contributing to Heat Tolerance in Creeping Bentgrass (Agrostis Stolonifera). Scientific Reports. 2016, 6: 30338.PubMed ID: 27455877

    The article reveals that the increased GABA shunt could be the supply of intermediates to feed the tricarboxylic acid cycle of respiration metabolism during long-term heat stress, thereby maintaining metabolic homeostasis.

  4. Jiménez-Jiménez F.J., et al. Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome. Pharmacogenomics J. 2018, 5. PubMed ID: 29720720

    The research suggests that GABRR3rs832032 polymorphism is associated with the risk for RLS, and there is a modifier effect of GABRA4 rs2229940 on the age of onset of RLS.

  5. García-Martín E., et al. Gamma-Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine. Headache. 2017, 57 (7):1118-1135. PubMed ID: 28699326

    The results suggest that GABRR genes seem to be not associated with the risk of migraine in Caucasian Spanish people.

GABRR3 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GABRR3 antibody development services.


Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

Reference

  1. Strauss O. (2011). The organization of the retina and visual system. The retinal pigment epithelium.

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