Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Galanin receptor 2 |
| Gene Name | GALR2 |
| Uniprot | O43603 (Human); O88854 (Mouse) |
| Synonym | GAL2-R; GALNR2; GALR-2; galanin receptor type 2 |
| Background | The GalR2 receptor was first cloned from a rat, it contains 372 amino acid residues and its coding gene has an intron. Exon 1 encodes from the N-terminus of the receptor to the end of the third transmembrane segment, and exon 2 encodes the second intracellular loop to the C-terminus. The extracellular domain of the rat GalR2 receptor has three nitrogen-linked glycosylation sites, while the intracellular domain has a different phosphorylation site than the GalR1 receptor. The C-terminus of the human GalR2 receptor is 15 amino acid residues more than the GalR2 receptor in the rat, and its GalR1 and GalR2 receptors are only about 42% homologous, suggesting that these two receptors have different regulatory functions. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX259 | NativeExtract™ Human GALR2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3515K | MemDX™ Membrane Protein Human GALR2 (Galanin receptor 2) Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
Au***ian: Ideal for structural studies and ligand screening, ensuring reproducible results in membrane protein research.
13/Aug/2023
Ce***tyn: Their custom GALR2 service delivered protein within 3 weeks, tailored to our specifications.
25/Mar/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Receptor-Specific AAV Vector Delivery
Creative Biolabs offers receptor-specific AAV vector delivery services. Adeno-associated virus (AAV) vectors engineered for GALR2-specific transduction enable localized delivery of therapeutic payloads to neural or metabolic tissues. For instance, preclinical studies demonstrate that AAV9 vectors encoding GALR2 agonists mitigate neuroinflammation and enhance synaptic plasticity in rodent models of Alzheimer's disease by modulating calcium-dependent signaling cascades. This approach ensures precise receptor activation while minimizing off-target effects, a critical advantage for neurodegenerative disorder interventions. Creative Biolabs' vector engineering expertise supports tailored AAV designs for GALR2 tissue specificity.
Receptor Modulation
Creative Biolabs offers receptor modulation services. Transcriptional activation or repression of GALR2 expression offers a novel strategy for metabolic syndrome management. In hypothalamic neurons, GALR2 upregulation enhances insulin sensitivity via PLC-IP3 pathway potentiation, counteracting diet-induced obesity in murine models. Conversely, targeted GALR2 knockdown in adipose tissue reduces lipogenesis, demonstrating therapeutic versatility. Creative Biolabs' proprietary RNA libraries enable rapid identification of high-efficiency guides for such applications.
Creative Biolabs offers comprehensive and innovative services to drive the development of GALR2 cell therapy. Please for more services.
Engineered Neuronal Progenitor Cell Implants
Creative Biolabs offers engineered neuronal progenitor cell implants development services. Transplanting GALR2-overexpressing neuronal progenitors into damaged CNS regions restores neurotransmitter homeostasis in Parkinson's disease models. These cells secrete galanin analogs that suppress neurotoxic α-synuclein aggregation through GALR2-mediated PKC activation, while concurrently enhancing dopaminergic neuron survival. Creative Biolabs' differentiation protocols ensure reproducible production of therapeutic-grade neural lineages.
CAR-T Cell Platforms for Neuroendocrine Targeting
Creative Biolabs offers CAR-T cells development services for neuroendocrine targeting. Chimeric antigen receptor (CAR)-T cells engineered to recognize GALR2-enriched tumor microenvironments (e.g., glioblastoma) deliver localized cytotoxic payloads or immunomodulatory cytokines. Preliminary data show that GALR2-directed CAR-Ts synergize with checkpoint inhibitors, achieving >60% tumor regression in xenograft models by disrupting cancer stem cell self-renewal pathways. Creative Biolabs' immune cell engineering services optimize CAR construct affinity and safety profiles for such specialized applications.
To explore how these methodologies can be customized for your research or clinical objectives, Creative Biolabs' multidisciplinary team provides end-to-end support from target validation to IND-enabling studies. to design a development roadmap leveraging our GALR2-focused in vivo models, receptor profiling assays, and scalable AAV/cell manufacturing platforms.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
