Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Galanin receptor 3 |
| Gene Name | GALR3 |
| Uniprot | O60755 (Human); O88853 (Mouse) |
| Synonym | galanin receptor type 3; GAL3-R; GALR-3; galanin receptor, family member 3 |
| Background | The GalR3 receptor was first cloned in rats and contained 370 amino acid residues. The human GalR3 receptor contains 368 amino acid residues, and its gene also has an intron at the same position as the GalR2 receptor gene, suggesting that the GalR2 and GalR3 receptors may have the same evolutionary origin. It shares higher homology with the human GalR2 receptor (about 58%) than human GalR1 receptor (about 38%). Human GalR3 receptor has about 90% homology with rat and is equally conserved N-terminal glycosylation sites and several phosphorylation sites, including a C-terminal PKC phosphorylation site not found in the GalR1 and GalR2 receptors. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX258 | NativeExtract™ Human GALR3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3475K | MemDX™ Membrane Protein Human GALR3 (Galanin receptor 3) Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
T***or: Reliable technical specifications and rapid fulfillment.
27/Apr/2023
J***an: Exceptional custom modification service met precise molecular requirements for chimeric receptor projects.
04/Jun/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
GALR3 Knockout for Insulin Resistance Mitigation
Creative Biolabs offers GALR3 knockout services for insulin resistance mitigation. Gene editing systems enable precise genomic deletion of GALR3, a therapeutic strategy validated in preclinical models of metabolic dysregulation. Studies demonstrate that GALR3 knockout in murine adipocytes suppresses macrophage-derived Gal-3 secretion, restoring insulin receptor signaling and reversing glucose intolerance. Creative Biolabs' RNA design platforms optimize specificity for GALR3 exons, minimizing off-target effects while achieving >90% editing efficiency in primary cells. This approach holds transformative potential for diabetes management, particularly in patients with elevated serum Gal-3 levels.
shRNA-Based Transcriptional Silencing in Hepatic Fibrosis
Creative Biolabs offers shRNA-based transcriptional silencing services. Lentiviral delivery of short hairpin RNA (shRNA) targeting GALR3 mRNA effectively reduces collagen deposition in fibrotic liver models. For instance, in vivo administration of GALR3-specific shRNA via AAV8 vectors decreased α-SMA+ myofibroblast activation by 62% in carbon tetrachloride-induced cirrhosis. Creative Biolabs' proprietary shRNA libraries include tissue-specific promoters for hepatocyte-selective silencing, ensuring localized therapeutic action without systemic toxicity.
Creative Biolabs offers comprehensive and innovative services to drive the development of GALR3 cell therapy. Please for more services.
Macrophage-Tropic AAV Vectors for Cardiac Gal-3 Neutralization
Creative Biolabs offers macrophage-tropic AAV vectors development services. AAV serotypes engineered for macrophage tropism deliver dominant-negative Gal-3 mutants into cardiac-infiltrating immune cells, mitigating atrial fibrosis. In hypoxia-induced pulmonary hypertension models, this strategy reduced right ventricular hypertrophy by 38% and normalized collagen I/III ratios. Creative Biolabs' AAV capsid screening platform identifies variants with 15-fold enhanced macrophage transduction, ideal for targeting Gal-3+ inflammatory niches.
CAR-Macrophage Therapies for Gal-3 Clearance in Chronic Inflammation
Creative Biolabs offers CAR-macrophage development services for Gal-3 clearance in chronic inflammation. Chimeric antigen receptor (CAR)-macrophages engineered with Gal-3-specific scFv domains selectively phagocytose extracellular Gal-3 aggregates in fibrotic tissues. Preliminary data in murine non-alcoholic steatohepatitis (NASH) models show 50% reduction in hepatic Gal-3 deposits post-infusion, paralleling improved histologic activity indices. Creative Biolabs offers lentiviral vector engineering services to streamline CAR integration and macrophage polarization protocols.
From gene editing to clinically translatable AAVs, Creative Biolabs delivers cutting-edge tools for GALR3 modulation. to co-develop a customized therapeutic strategy.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
