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Gap Junction Protein Family

Gap junction proteins, also called connexins, are a group of more than 20 highly conserved proteins with developmental and tissue-specific expression patterns, which mediate gap junction intercellular communication. One gap junction is composed of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW (molecular weight) diffuse from one cell to a neighboring cell. In vertebrate animals, gap junctions are formed by two connexons (or hemichannels), one provided by each of two cells. Each connexon consists of six oligomerized connexin proteins (Cx for short), which can be either homomeric or heteromeric (two or more different connexins in one connexon) and form homotypic or heterotypic (different connexons) gap junction channels. Gap junction can directly connect the cytoplasm of two cells, which allows various ions, molecules, electrical impulses to directly pass through a regulated gate between cells.

Intercellular communication of gap junctions plays a vital role in normal development and physiology with a loss of function implicated in various human diseases such as peripheral nerve disorders and nonsyndromic deafness. Here, we show part of the gap junction protein family members, for which we can give you more detailed description.

Human Gap Junction Protein Family Members
GJA1 GJA10 GJA3 GJA5 GJA8
GJB1 GJB2 GJB3 GJC1 GJC2
GJD2 GJD3 GLDN    

Based on our efficient Magic™ membrane protein production platform, Creative Biolabs can offer the preparation of these membrane proteins given above in required formats utilizing different strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with the stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Additionally, our Magic™ membrane protein antibody discovery platform can be applied in developing antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.

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