Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsGap junction proteins, also called connexins, are a group of more than 20 highly conserved proteins with developmental and tissue-specific expression patterns, which mediate gap junction intercellular communication. One gap junction is composed of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW (molecular weight) diffuse from one cell to a neighboring cell. In vertebrate animals, gap junctions are formed by two connexons (or hemichannels), one provided by each of two cells. Each connexon consists of six oligomerized connexin proteins (Cx for short), which can be either homomeric or heteromeric (two or more different connexins in one connexon) and form homotypic or heterotypic (different connexons) gap junction channels. Gap junction can directly connect the cytoplasm of two cells, which allows various ions, molecules, electrical impulses to directly pass through a regulated gate between cells.
Intercellular communication of gap junctions plays a vital role in normal development and physiology with a loss of function implicated in various human diseases such as peripheral nerve disorders and nonsyndromic deafness. Here, we show part of the gap junction protein family members, for which we can give you more detailed description.
| Human Gap Junction Protein Family Members | ||||
| GJA1 | GJA10 | GJA3 | GJA5 | GJA8 |
| GJB1 | GJB2 | GJB3 | GJC1 | GJC2 |
| GJD2 | GJD3 | GLDN | ||
Based on our efficient MemDX™ membrane protein production platform, Creative Biolabs can offer the preparation of these membrane proteins given above in required formats utilizing different strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, with the stable cell line.
Additionally, our MemDX™ membrane protein antibody discovery platform can be applied in developing antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
