shRNA Adenovirus Serotype 5 (ΔE1/E3), p7SK-(JOSD2-shRNA-Seq2)(CAT#: AdV-SI1374WQ)
This product is a JOSD2-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The JOSD2 gene encodes a protein containing a Josephin domain. Josephin domain-containing proteins are deubiquitinating enzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and protein substrates. The expression of JOSD2-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | HAdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Insert | JOSD2-shRNA-Seq2 |
| Related Target/Protein | JOSD2 |
| Region | CDS |
| TargetSeq | GTGTCTACTACAACCTGGACT |
| NCBI RefSeq | NM_138334 |
| Alternative Names | SBBI54 |
| Titer | >1*10^10 GC/mL |
