shRNA Adenovirus Serotype 5 (ΔE1/E3), p7SK-(NECAP1-shRNA-Seq2)(CAT#: AdV-SI1473WQ)
This product is a NECAP1-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The NECAP1 gene encodes a protein containing two characteristic WXXF motifs and the encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. The expression of NECAP1-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | HAdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Insert | NECAP1-shRNA-Seq2 |
| Related Target/Protein | NECAP1 |
| Region | CDS |
| TargetSeq | CTTCGACTTTAATGTCTCCTT |
| NCBI RefSeq | NM_015509 |
| Alternative Names | EIEE21 |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Retinal Degeneration |
