shRNA Adenovirus Serotype 5 (ΔE1/E3), pH1-(Gaa-shRNA-Seq1)(CAT#: AdV-SI3087WQ)
This product is a Gaa-shRNA encoding AdV, which is based on AdV-5 serotype with E1/E3 gene deleted. The Gaa gene encodes lysosomal alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. The expression of Gaa-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | AdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Modification | ΔE1/E3 |
| Insert | Gaa-shRNA-Seq1 |
| Related Target/Protein | Gaa |
| Region | 3UTR |
| TargetSeq | CCCTGAAGCTCTGTGTTCTTA |
| NCBI RefSeq | NM_008064 |
| Alternative Names | LYAG |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Pompe's disease |
