shRNA Adenovirus Serotype 5 (ΔE1/E3), pH1-(Psme4-shRNA-Seq2)(CAT#: AdV-SI2572WQ)

This product is a Psme4-shRNA encoding AdV, which is based on AdV-5 serotype with E1/E3 gene deleted. The protein encoded by Psme4 gene is associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. The expression of Psme4-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.