shRNA Adenovirus Serotype 5 (ΔE1/E3), pH1-(THOC1-shRNA-Seq4)(CAT#: AdV-SI0533WQ)

This product is a THOC1-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. THOC1, also known as HPR1, is part of the TREX (transcription/export) complex and participate in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. The expression of THOC1-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.