shRNA Adenovirus Serotype 5 (ΔE1/E3), pH1-(TSR2-shRNA-Seq2)(CAT#: AdV-SI0783WQ)
This product is a TSR2-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by TSR2 gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. The expression of TSR2-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | HAdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Insert | TSR2-shRNA-Seq2 |
| Related Target/Protein | TSR2 |
| Region | CDS |
| TargetSeq | GATTACTTCATGCGCAATGCT |
| NCBI RefSeq | NM_058163 |
| Alternative Names | WGG1; DBA14; DT1P1A10 |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Diamond-Blackfan anemia |
