shRNA Adenovirus Serotype 5 (ΔE1/E3), pH1-(VARS2-shRNA-Seq1)(CAT#: AdV-SI2383WQ)

This product is a VARS2-shRNA encoding AdV, which is based on AdV-5 serotype with E1/E3 gene deleted. The VARS2 encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. The expression of VARS2-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.