shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(C8orf4-shRNA-Seq1)(CAT#: AdV-SI0061WQ)
This product is a C8orf4-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The C8orf4 gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. The expression of C8orf4-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | HAdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Insert | C8orf4-shRNA-Seq1 |
| Related Target/Protein | C8orf4 |
| Region | CDS |
| TargetSeq | GAGACAAGAAAGCAGAGGAGA |
| NCBI RefSeq | NM_020130 |
| Alternative Names | TC1; TC-1; TCIM |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Thyroid cancer, breast cancer and hematological malignancies |
