shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(CCDC67-shRNA-Seq1)(CAT#: AdV-SI0194WQ)
This product is a CCDC67-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The CCDC67 gene is key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. The expression of CCDC67-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | HAdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Insert | CCDC67-shRNA-Seq1 |
| Related Target/Protein | CCDC67 |
| Region | CDS |
| TargetSeq | CGTTTGATATGTGACCCAGAT |
| NCBI RefSeq | NM_181645 |
| Alternative Names | DEUP1 |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Papillary thyroid carcinoma, gastric cancer |
