shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(GEMIN8-shRNA-Seq1)(CAT#: AdV-SI0169WQ)
This product is a GEMIN8-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by GEMIN8 gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The expression of GEMIN8-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | HAdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Insert | GEMIN8-shRNA-Seq1 |
| Related Target/Protein | GEMIN8 |
| Region | CDS |
| TargetSeq | GAGTCAGATGCAGAGGTAGAA |
| NCBI RefSeq | NM_017856 |
| Alternative Names | FAM51A1 |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Survival motor neuron (SMN) |
