shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(KCTD2-shRNA-Seq3)(CAT#: AdV-SI0418WQ)
This product is a KCTD2-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc. The expression of KCTD2-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | HAdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Insert | KCTD2-shRNA-Seq3 |
| Related Target/Protein | KCTD2 |
| Region | CDS |
| TargetSeq | CGGGACAATGAGAACAGAACT |
| NCBI RefSeq | NM_015353 |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Ischaemic Stroke and Alzheimer's Disease |
