shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(Ola1-shRNA-Seq4)(CAT#: AdV-SI1738WQ)
This product is a Ola1-shRNA encoding AdV, which is based on AdV-5 serotype with E1/E3 gene deleted. The Ola1 gene encodes a member of the GTPase protein family and interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. The expression of Ola1-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | AdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Modification | ΔE1/E3 |
| Insert | Ola1-shRNA-Seq4 |
| Related Target/Protein | Ola1 |
| Region | 3UTR |
| TargetSeq | CATGGGAATTAGAAGAAGAAT |
| NCBI RefSeq | NM_025942 |
| Alternative Names | DOC45; GBP45; GTBP9; GTPBP9; PTD004 |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Breast cancer |
