shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(SF3B4-shRNA-Seq3)(CAT#: AdV-SI0041WQ)
This product is a SF3B4-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by SF3B4 gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. The expression of SF3B4-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | HAdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Insert | SF3B4-shRNA-Seq3 |
Related Target/Protein | SF3B4 |
Region | CDS |
TargetSeq | CACCGTATCTTATGCCTTCAA |
NCBI RefSeq | NM_005850 |
Alternative Names | AFD1; Hsh49; SAP49; SF3b49 |
Titer | >1*10^10 GC/mL |
Related Diseases | Hepatocellular carcinoma |