shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(Tmem146-shRNA-Seq1)(CAT#: AdV-SI1976WQ)
This product is a Tmem146-shRNA encoding AdV, which is based on AdV-5 serotype with E1/E3 gene deleted. The Tmem146 gene encodes auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. The expression of Tmem146-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | AdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Modification | ΔE1/E3 |
| Insert | Tmem146-shRNA-Seq1 |
| Related Target/Protein | Tmem146 |
| Region | CDS |
| TargetSeq | CCAGGATGACCTGATAGTATT |
| NCBI RefSeq | XM_001052081 |
| Alternative Names | CATSPERD |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Infertility |
