shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(TSR2-shRNA-Seq2)(CAT#: AdV-SI0282WQ)

This product is a TSR2-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by TSR2 gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. The expression of TSR2-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.